Cardiothoracic Surgery Clinical Trial
Official title:
Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery
Evaluation of Liposomal Bupivacaine Compared to Usual Care and its Effect on Pain for Cardiac Surgery
Current standard of care for pain management includes a multimodal approach of peristernal
and fifth intercoastal infiltration with 0.25% bupivacaine with epinepherine combined with
immediate post operative IV acetaminophen, followed by scheduled oral acetaminophen and
supplemental IV and PO narcotics. This practice is beneficial since it controls most of the
direct surgical site pain for at least 6 hours, however, after the local anesthetic
dissipates, pain is usually managed with the use of opioids combined with scheduled oral
acetaminophen.
Opioids are the most commonly used medications to control pain early after surgery because of
their high potency. However, their undesirable effects and risk of dependence become
limitations.
The Investigators believe Liposomal Bupivacaine would be beneficial in this population due to
its quick onset of action and prolonged half-life associated with liposomal formulation
ranging from 23.8 to 34.1 hours. The primary endpoint will be a 20% reduction in opioids use.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05968456 -
Complexity and Frailty in Cardiothoracic and Vascular Anesthesia (CAfCA). Prospective Multicentric Observational Study
|
||
| Not yet recruiting |
NCT05079724 -
Acute Kidney Injury After Cardiac Surgery
|
||
| Completed |
NCT01847859 -
Pocket-size Ultrasound by Nurses in Cardiothoracic Post-operative Patients
|
N/A | |
| Terminated |
NCT01897519 -
A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Surgery
|
Phase 2 | |
| Recruiting |
NCT02863250 -
Australian and New Zealand Massive Transfusion Registry
|
||
| Completed |
NCT03725098 -
Clinical Study Evaluating the Performance of HEMOBLAST Bellows Compared to FLOSEAL Hemostatic Matrix in Cardiothoracic Operations
|
N/A | |
| Terminated |
NCT00075179 -
Natrecor in Pulmonary Hypertension
|
Phase 4 | |
| Recruiting |
NCT02029534 -
Intensive Statin Therapy Effect on Post-Operative Atrial Fibrillation (POAF)
|
Phase 4 | |
| Recruiting |
NCT03639519 -
A Trial to Assess the Impact of Ascorbic Acid on Cardiac Surgeries Outcomes and Complications''
|
Phase 4 |