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Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement

Cardiopulmonary Bypass Clinical Trial

Official title:
Effects of Ischemic Postconditioning on Expression of Apoptosis-related MicroRNAs and Genes in Human Double Valve Replacement

Clinical Trial Summary

1. Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral).

2. The modulation of myocardial microRNAs by cardiopulmonary bypass and cardioplegic arrest may be rescued by ischemic postconditioning.

3. Downstream effectors would also be affected.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01804283
Study type Interventional
Source Central South University
Contact
Status Not yet recruiting
Phase N/A
Start date March 2013
View Details
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