Cardiomyopathy Clinical Trial
— GENECHOCOfficial title:
Identification of Genetic Markers Modulating Rhythmic Risk Among Patients With Severe Cardiomyopathy
Verified date | January 2018 |
Source | Nantes University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The aim of this project is to identify common genetic polymorphisms associated with the occurrence of rhythmic events in patients with severe cardiomyopathy.
Status | Completed |
Enrollment | 1500 |
Est. completion date | November 2017 |
Est. primary completion date | November 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients implanted for primary prevention, an implantable cardioverter defibrillator (ICD) single or double room, for severe cardiomyopathy (EF <35%) - Patients with ischemic cardiomyopathy or idiopathic dilated cardiomyopathy.- "Appropriate treatment" group: patients who had a rhythmic event (before or after inclusion) appropriately treated either by administering an electric shock or by antiarrhythmic stimulation - Group "no event" patients who have never received treatment or electrical antiarrhythmic stimulation and with a minimum follow-up of three years before inclusion and did not receive proper treatment during the follow up period of the study Exclusion Criteria: - Patients implanted with an ICD for primary prevention in the context of a family hereditary disease (long QT syndrome, Brugada syndrome, hypertrophic cardiomyopathy, ventricular tachycardia catecholergic right ventricular dysplasia ...). - Patients with left ventricular function greater than 35%. - Patients implanted with a defibrillator function resynchronization. - Patients minors, adults under guardianship and protected persons are eligible under this project. |
Country | Name | City | State |
---|---|---|---|
France | CHU Angers | Angers | |
France | CHU Bordeaux | Bordeaux | |
France | CHU Brest | Brest | |
France | CHU Clermont-Ferrand. | Clermont-Ferrand | |
France | CHU Dijon | Dijon | |
France | CHU Grenoble | Grenoble | |
France | CH La Rochelle | La Rochelle | |
France | CHRU Lille | Lille | |
France | CHU Lyon | Lyon | |
France | CHU Marseille | Marseille | |
France | CHU Montpellier | Montpellier | |
France | CHU Nancy | Nancy | |
France | CHU Nantes | Nantes | |
France | CHU Rennes | Rennes | |
France | CHU Rouen | Rouen | |
France | CHRU Strasbourg | Strasbourg | |
France | CHU Toulouse | Toulouse | |
France | CHU Tours | Tours |
Lead Sponsor | Collaborator |
---|---|
Nantes University Hospital |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prevalence of polymorphisms pre-selected candidates (or by direct sequencing by High Resolution Melting). | 4 years | ||
Primary | Identification of polymorphisms frequent (> 5% in the general population) by association study ( "Genome Wide Association Study '(GWAS)) using genotyping technology broadband Axiom (Affymetrix). | 4 years |
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