Cardiomyopathy Clinical Trial
Official title:
Resistance and Aerobic Exercise for Subclinical Anthracycline Cardiomyopathy
This application proposes a prospective, single arm feasibility clinical trial of a 12-week
period of combined endurance and resistance training in survivors of childhood cancer who
were treated with doxorubicin and/or daunorubicin and have impaired cardiac function.
Baseline and post intervention imaging, laboratory, and neuropsychological evaluations will
be used to determine the effects of the intervention on body composition, serum lipid
profile, exercise tolerance, and neurocognitive functioning. Participants will be called
weekly to monitor compliance with the intervention. Incentives will be given at intervals
during the trial to optimize compliance with the intervention.
This study will evaluate the feasibility of a 12-week exercise intervention on the cardiac
function of survivors of childhood cancer treated with anthracyclines and known to have
cardiomyopathy.
As a secondary objective, the study will document the effect of a 12-week exercise
intervention on exercise tolerance, as determined by measurement of peak VO2 and peak
exercise workload, shortening fraction, ejection fraction, and left ventricular wall
thickness, and assess the impact of the intervention on neurocognitive functioning in
survivors of childhood cancer treated with anthracyclines and known to have cardiomyopathy.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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