Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients

Cardiomyopathies Clinical Trial

— COCARDE  

Official title:

Imaging Cardiac Phenotype of SARS-Cov-2 (Covid19) Infected Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04358952
• Other study ID #: RC31/20/0117
• Secondary ID: 2020-A00852-37
• Status: Completed
• Start date: April 4, 2020
• Est. completion date: April 2, 2021

Study information

• Verified date: May 2021
• Source: University Hospital, Toulouse
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The effects of severe acute respiratory syndrome SARS-Cov-2 (Covid-19) on the myocardium and their role in the clinical course of infected patients are still unknown. Epidemiological studies report biological myocardial involvement in 10 to 25% of cases. The objective of this study is to cardiac phenotype using comprehensive cardiac imaging tools of patients infected with Covid 19 in order to explore the functional impact of the infection on the myocardium.

Description:

A large population of Covid 19 infected patients of different ages and severity levels will be explored by transthoracic echocardiography with measurement of myocardial functional parameters such as ejection fraction, longitudinal strain and relaxation parameters and will be compared to an uninfected population paired for age and sex.

Patients with biological myocardial involvement will be followed to determine the evolution of their myocardial functional parameters during the course of the infection.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 122
• Est. completion date: April 2, 2021
• Est. primary completion date: April 2, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR

Exclusion Criteria:

• Underage patients. Patients refusing to participate in research. Patients with a history of heart disease.

Related Conditions & MeSH terms

• Cardiomyopathies

Intervention

Diagnostic Test:
• Global Longitudinal Strain
Electrocardiogram with measure of the Global Longitudinal Strain to evaluate myocardiac dysfunction

Locations

Country	Name	City	State
France	UHToulouse	Toulouse

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Toulouse

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Left ventricular function	Left ventricular function evaluated by global longitudinal strain	Day 0
Primary	Left ventricular function	Left ventricular function evaluated by global longitudinal strain	Day 3
Primary	Left ventricular function	Left ventricular function evaluated by global longitudinal strain	Day 7
Secondary	inflammatory biological parameters	Cytokine rate	Day 0