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Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile

Cardiometabolic Syndrome Clinical Trial

Official title:
Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile: the SPICE Study

Clinical Trial Summary

Among food products receiving attention for prebiotic functionality, spices represent a flavorful vehicle for cultivating a healthy gut microbiota. As the required doses of spice-derived polyphenols to elicit prebiotic and systemic metabolic effects are not well-characterized, additional research is warranted. Thus, the investigators propose to use a food-first synbiotic (prebiotic + probiotic) approach to examine alterations in the gut microbiota pre- and post-intervention/placebo and their relationship with systemic cardiometabolic effects mediated by short chain fatty acids (SCFA) and gut-derived metabolites.

Clinical Trial Description

Study will be conducted as a single blind, randomized crossover design with a 4-week arm (placebo or control) followed by a 2-week washout period and another 4-week arm (placebo or control). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06313580
Study type Interventional
Source University of Alabama, Tuscaloosa
Contact Kristi M Crowe-White, PhD, RD
Phone 205-348-6173
Email kcrowe@ches.ua.edu
Status Recruiting
Phase N/A
Start date January 1, 2023
Completion date June 2025
View Details
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