Cardiac Surgical Procedures Clinical Trial
Official title:
Perioperative Blood Glucose Variability and Autonomic Nervous System Activity in On-pump Cardiac Surgery Patients: Study Protocol of a Single-center Observational Study.
On-pump coronary artery bypass graft (CABG) and valve replacement surgeries are high-risk procedures. Among the risk factors for postoperative complications, perioperative hyperglycemia and blood glucose variability have been reported to be associated with increased morbidity and mortality. The treatment of hyperglycemia using intravenous insulin infusion improves the prognosis in cardiac surgery patients. However, the determinants of postoperative blood glucose variability and the mechanisms leading to its deleterious impact are unknown. Thus, to date, there is no therapeutic intervention that could effectively prevent and treat the deleterious impact of glycemic variability on postoperative outcome. The purpose of the study is to evaluate whether perioperative alteration of the autonomic nervous system and preoperative blood glucose variability could be related to perioperative glycemic variability.
The main objective is to describe the relationship between preoperative glycemic variability and glycemic variability during the first 48 postoperative hours. The secondary objectives are : 1. to describe the relationship between preoperative glycemic variability and glycemic variability during the first 48 hours postoperative according to: - diabetic and non-diabetic status - the type of surgical intervention 2. to describe the relationship between the parameters evaluating the preoperative activity of the autonomic nervous system and: - preoperative glycemic variability - glycemic variability during the first 48 postoperative hours 3. to describe the relationship between glycemic variability during the first 48 postoperative hours and: - parameters evaluating the activity of the autonomic nervous system during the first 48 postoperative hours - diabetes phenotype - markers of inflammation - markers of endothelial dysfunction 4. to describe the morbidity and mortality within 30 days after surgery. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT04293744 -
Acute Kidney Injury After Cardiac Surgery
|
N/A | |
Completed |
NCT01184521 -
Masimo CO-Oximeter Study
|
Phase 0 | |
Completed |
NCT05537168 -
Bayesian Networks in Pediatric Cardiac Surgery
|
||
Completed |
NCT05737147 -
Comparison of the Accuracy and Precision of a Zero Heat Flux Thermometer (SpotOn) Versus Pulmonary Artery Temperature.
|
||
Completed |
NCT04269109 -
Opioid Sparing Pain Management Strategy
|
||
Completed |
NCT04911413 -
Comparison of Three Tranexamic Acid Dose Regimens in Patients Undergoing Cardiac Valve Surgery
|
Phase 4 | |
Recruiting |
NCT02580292 -
Diagnostic Accuracy of Doppler Resistive Indices for Early Diagnosis of Acute Kidney Injury .
|
||
Completed |
NCT02457572 -
Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition
|
N/A | |
Completed |
NCT00997217 -
The Effect of Remote Ischemic Preconditioning in the Cardiac Surgery
|
Phase 1 | |
Completed |
NCT01169441 -
Lead Extract Study
|
N/A | |
Completed |
NCT00336908 -
Inflammatory Responses to Lipid Emulsions in Children Before and After Open Heart Surgery
|
Phase 2/Phase 3 | |
Terminated |
NCT05308589 -
CPPF After General Cardiac Surgery
|
N/A | |
Recruiting |
NCT03163238 -
Dexmedetomidine and the Inflammatory Response in Pediatric Cardiac Surgery
|
Phase 2 | |
Completed |
NCT02329158 -
Disinvestment in Hydroxyl-ethyl Starches (HES) for Cardiac Surgery
|
||
Completed |
NCT01029314 -
Pilot Study of the Genius(TM)2 Tympanic Thermometer in Cardiac Patients Requiring Cardiopulmonary Bypass
|
N/A | |
Completed |
NCT00459082 -
A Pharmacokinetic Study of Dexmedetomine in Infants
|
Phase 1 | |
Completed |
NCT00122018 -
An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
|
Phase 2 | |
Terminated |
NCT03709693 -
Clinical Outcomes in Patients Treated With SternaLock Blu
|
||
Completed |
NCT03976947 -
Impact of Lung Recruitment Maneuvers on Driving Pressure in Cardiac Surgery
|
||
Completed |
NCT02398019 -
Clinical Trial to Evaluate the Use of an Adsorption Membrane (oXiris®) During Cardiopulmonary Bypass Surgery
|
N/A |