Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction(POCD)

Cardiac Surgery Patients Clinical Trial

Official title:

Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction After On-pump Cardiac Surgery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02084030
• Other study ID #: DONG2014POCD
• Status: Recruiting
• Phase: N/A
• First received: March 4, 2014
• Last updated: August 14, 2014
• Start date: March 2013
• Est. completion date: September 2014

Study information

• Verified date: August 2014
• Source: Xijing Hospital
• Contact: Hailong DONG, MD, PhD
• Phone: 86-2984775337
• Email: hldong6[@]hotmail.com
• Is FDA regulated: No
• Health authority: China: National Natural Science FoundationChina: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

The aim of this study is to perform a whole-genome linkage analysis for identification of the susceptibility loci for POCD

Description:

BACKGROUND: Postoperative cognitive dysfunction is probably the most frequent type of postoperative cognitive impairment. As it mainly affect the elderly population, POCD is receiving increasing attention. However, the pathophysiology of POCD remains incompletely understood. No study had elucidate why somebody are apt to suffer from POCD, but others not. In current study, we try to use GWAS technology to find out whether there is a correlation between POCD and gene specificity.

DESIGNING: 120 patients will be screened who are schedule to receive selective on-pump cardiac surgery， 5 ml blood of the patient will be collected before anesthesia induction. Investigetors will measure the cognitive function of the patients one day before surgery and 7 d after surgery and identify whether the patient suffer from POCD used in MMSE test. Randomly select 36 patients who suffer from POCD and 36 patients without POCD(control), GWAS technology will be used to screen the susceptibility gene between these two groups.

EXPECTED RESULTS ：Find out some susceptibility genes correlate to POCD.

CONCLUSIONS: The patients who are apt to suffer from POCD have some special susceptibility genes differ from normal people.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: September 2014
• Est. primary completion date: September 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 60 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Age from 60 to 75 years old;

2. Schedule for on-pump cardiac surgery;

3. undergoing full intravenous anesthesia;

4. without hepatic, renal, pulmonary disease or full intravenous anesthesia surgery history;

5. Gave the informed consent.

Exclusion Criteria:

1. Emergency surgery;

2. A history of cerebrovascular disease;

3. The history of mental disease;

4. Long term use of sedative and antidepressant drugs;

5. Alcoholism;

6. serious vision, hearing impairment and inapprehensive language;

7. chromosomal abnormalities;

8. blood disease;

9. refused to sign the informed consent.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Cardiac Surgery Patients
• Cognition Disorders
• Disease Susceptibility

Locations

Country	Name	City	State
China	Xijing Hospital	Xi'an	Shaanxi

Sponsors (1)

Lead Sponsor	Collaborator
Xijing Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	single nucleotide polymorphisms(SNPs) of each patient		about 10 minutes before anesthesia induction	No
Secondary	mini-mental state examination scale	the cognitive function	one day before surgery, 7 d after surgery	No