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NCT03609333 Clinical Trial

Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation

Cardiac Arrest Clinical Trial

— CAMPHIBIII  

Official title:
Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation in Hypoxic Ischemic Brain Injury After Cardiac Arrest

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03609333
Other study ID # H16-00466
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date November 12, 2016
Est. completion date June 30, 2020

Study information
Verified date November 2020
Source University of British Columbia
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Hypoxic ischemic brain injury is a devastating illness that occurs after cardiac arrest (the heart stopping) and can yield irreversible brain damage, often leading to death. The mainstay in therapy is to optimize the delivery of oxygen to the brain to help it recover. In patients with traumatic brain injury (similar to HIBI), the investigators are able to optimize oxygen delivery to the brain with the use of wires placed into the brain that sense the pressure and oxygen in the skull to find the ideal blood pressure for each individual patient. This strategy is associated with improved outcomes. The investigators are conducting a prospective study investigating whether the perfusion within proximity to the optimal MAP is associated with improved brain oxygenation and blood flow .

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date June 30, 2020
Est. primary completion date June 30, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Confirmed cardiac arrest with return of spontaneous circulation > 10 minutes - post resuscitation GCS < 9 Exclusion Criteria: - concurrent coagulopathy - prior history of TBI, intracranial hemorrhage, subarachnoid hemorrhage - anticipated cardiac catheterization within next 7 days - anticipated or current use of anticoagulants or anit-platelets

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• Multimodal Neuromonitoring
Application of multimodal neuromonitoring

Locations
Country Name City State
Canada Vancouver General Hospital Vancouver British Columbia

Sponsors (1)
Lead Sponsor Collaborator
University of British Columbia

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Cerberal blood flow mls/100g/min 12 hours
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