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NCT03571074 Clinical Trial

Hyperoxia Before and After Cardiac Arrest and Myocardial Damage

Cardiac Arrest Clinical Trial

Official title:
Hyperoxia Before and After Cardiac Arrest and Myocardial Damage, a Retrospective Cohort Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03571074
Other study ID # HyperoxiaandCardiacarrest
Secondary ID
Status Completed
Phase
First received
Last updated
Start date May 30, 2018
Est. completion date September 30, 2018

Study information
Verified date October 2018
Source University Hospital Bispebjerg and Frederiksberg
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Several studies show how patients with hyperoxia after cardiac arrest has increased mortality, but the association of hyperoxia before cardiac arrest and myocardial damage has never been investigated. Neither has the association between hyperoxia after cardiac arrest and myocardial injury.

Our research hypothesis is that hyperoxia before cardiac arrest aggravates myocardial damage, secondly we wish to analyze the association between hyperoxia after cardiac arrest and myocardial injury.

The exposure variables is oxygenation within 48 hours before and 48 hours after cardiac arrest, our primary outcome is myocardial damage and will be measured as peak troponin within 30 days after cardiac arrest.

Recruitment information / eligibility
Status Completed
Enrollment 163
Est. completion date September 30, 2018
Est. primary completion date August 10, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- 18 years or older

- With a record of ICD-10 diagnosis of cardiac arrest in 2014, admitted to a hospital in the Capital Region of Denmark.

- First recorded cardiac arrest in 2014

- Admitted to ICU

- Serum troponin measured within 7 days after cardiac arrest

Exclusion Criteria:

- Out of hospital cardiac arrest, OHCA

- In of hospital cardiac arrest, IHCA, but with no registered saturation before cardiac arrest.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Oxygenation
Oxygenation measured as oxygen supply and saturation before cardiac arrest, and oxygenation measured as PaO2 after cardiac arrest.

Locations
Country Name City State
Denmark Bispebjerg Hospital Copenhagen

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Bispebjerg and Frederiksberg

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary Peak troponin within 30 days after cardiac arrest Troponin measurements on patients after cardiac arrest. 30 days
Secondary 30-day and 1-year mortality Up to 1 year.
Secondary Troponin area under the curve within 3 days after cardiac arrest 3 days
Secondary Length of ICU stay after cardiac arrest through study completion,on average of 4-8 weeks.
Secondary Length of hospital stay after cardiac arrest through study completion,on average of 4-8 weeks.
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