Ubiquinol as a Metabolic Resuscitator in Post-Cardiac Arrest

Status Completed

Clinical Trial Summary

To study the effects of ubiquinol as a "metabolic resuscitator" in post-cardiac arrest.

Clinical Trial Description

Cardiac arrest (CA) occurs in more than 400,000 patients in the United States each year with an estimated mortality of greater than 90%. The majority of patients who are resuscitated from CA will succumb to the neurologic morbidity associated with the post-CA syndrome and ischemic-reperfusion injury. Currently, there are no pharmacologic agents known to offer survival benefit or to prevent devastating neurologic injury in post-CA patients. A potential therapeutic target following ischemia-reperfusion injury is mitochondrial function in the injured cell and/or reduction of oxygen free radicals. Coenzyme Q10 (CoQ10) is an essential mitochondrial co-factor and free radical scavenger that has been proposed as a neuroprotective agent in various neurodegenerative disorders as well as a cardioprotective agent. CoQ10 have furthermore shown exciting preliminary results as a potential therapy in post-CA. In order to test the effects of ubiquinol as a "metabolic resuscitator" in post-CA patients and to provide additional preliminary data for a large-scale clinical trial, the investigators are conducting a randomized, double-blind, place-controlled trial of ubiquinol in post-CA patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02934555
Study type	Interventional
Source	Beth Israel Deaconess Medical Center
Contact
Status	Completed
Phase	Phase 2
Start date	March 2016
Completion date	June 2, 2019

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