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NCT01968148 Clinical Trial

Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest

Cardiac Arrest Clinical Trial

Official title:
Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01968148
Other study ID # 357/13/03/12/2012 § 205
Secondary ID
Status Completed
Phase N/A
First received October 19, 2013
Last updated March 11, 2018
Start date November 2013
Est. completion date July 30, 2015

Study information
Verified date March 2018
Source Helsinki University Central Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1).

Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples.

Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date July 30, 2015
Est. primary completion date July 30, 2015
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- age =18 years

- witnessed cardiac arrest

- interval form emergency call to return of spontaneous circulation 10-45 minutes

Exclusion Criteria:

- severe pre-arrest disability leading to withdrawing treatment in prehospital phase

- no concent from next of kin

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Finland Helsinki Emergency Medical Services Helsinki
Finland Helsinki Area Helicopter Emergency Medical Services Vantaa

Sponsors (1)
Lead Sponsor Collaborator
Helsinki University Central Hospital

Country where clinical trial is conducted

Finland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change in level of insulin 60 minutes
Primary Change in level of glucagon 60 minutes
Secondary Blood cortisol level 60 minutes after ROSC
Secondary Blood interleukin-6 level 60 minutes after ROSC
Secondary Change in blood glucose level 60 minutes
Secondary Change in level of GLP-1 60 minutes
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