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Cardiac Arrest clinical trials

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NCT ID: NCT02289651 Recruiting - Cardiac Arrest Clinical Trials

Effectiveness of Pediatric Intubation

PETI
Start date: November 2014
Phase: N/A
Study type: Interventional

We hypothesized that the Venner videolaryngoscope (A.P. Advanceā„¢) is beneficial for intubation of pediatric manikins while performing CPR. In the current study, we compared effectiveness of the Venner videolaryngoscope (A.P. Advanceā„¢) and MIL laryngoscopes in child resuscitation with and without CC.

NCT ID: NCT02289638 Recruiting - Cardiac Arrest Clinical Trials

Effectiveness of Child Intubation

Start date: November 2014
Phase: N/A
Study type: Interventional

We hypothesized that the Intubrite Video Laryngoscope System VLS 6600 is beneficial for intubation of pediatric manikins while performing CPR. In the current study, we compared effectiveness of the Intubrite and MIL laryngoscopes in child resuscitation with and without CC.

NCT ID: NCT02286323 Enrolling by invitation - Cardiac Arrest Clinical Trials

Endotracheal Intubation During Resuscitation

EIDR
Start date: November 2014
Phase: N/A
Study type: Interventional

We hypothesized that the BONFILS is beneficial for intubation of manikins while performing CPR. In the current study we compared the performance of the BONFILS and the Macintosh laryngoscopes with respect to their effectiveness and time to successful ETI during chest compression (CC) using an adult manikin.

NCT ID: NCT02283034 Recruiting - Cardiac Arrest Clinical Trials

Effectiveness of Pediatric Resuscitation

EPR
Start date: October 2014
Phase: N/A
Study type: Interventional

The aim of this study was to compare five CPR feedback devices to standard BLS in terms of the quality of single rescuer pediatric resuscitation. Therefore, the investigators hypothesis was that there would be no difference between CPR methods in terms of chest compression quality parameters.

NCT ID: NCT02281903 Completed - Cardiac Arrest Clinical Trials

Pediatric Resuscitation With Feedback CPR Devices

PRFD
Start date: October 2014
Phase: N/A
Study type: Interventional

The aim of this study was to compare the TrueCPR feedback device (with metronome) to standard basic life support (BLS) in terms of the quality of single rescuer pediatric resuscitation. Therefore, our hypothesis was that there would be no difference between both CPR methods in terms of chest compression quality parameters.

NCT ID: NCT02277015 Enrolling by invitation - Cardiac Arrest Clinical Trials

Intubation During Pediatric Resuscitation

Start date: October 2014
Phase: N/A
Study type: Interventional

The European Resuscitation Council (ERC) 2010 cardiopulmonary resuscitation (CPR) guidelines suggest that intubators should be able to secure the airway without interrupting chest compression. We examine the performance of the Berci-Kaplan DCI (BERCI), the GlideScope (GVL), the AirTraq, the Pentax AWS (Pentax) and the Miller laryngoscope (MIL) for endotracheal intubation (ETI) during pediatric resuscitation with and without chest compressions.

NCT ID: NCT02275234 Completed - Cardiac Arrest Clinical Trials

Care After Resuscitation

CARE
Start date: September 2014
Phase:
Study type: Observational

The purpose of this study is to investigate whether simple psychological interventions can be implemented at the Essex Cardiothoracic Centre (CTC) with a view to supporting the psychological wellbeing of survivors of cardiac arrest during their recovery.

NCT ID: NCT02260258 Completed - Cardiac Arrest Clinical Trials

Neuromuscular Blockade for Post-Cardiac Arrest Care

NMB_in_CA
Start date: October 2014
Phase: Phase 2
Study type: Interventional

The main purpose of this study is to evaluate if neuromuscular blockade improves lactate clearance (and preliminary secondary clinical outcome measures) as compared to usual care in post-cardiac arrest patients undergoing targeted temperature management.

NCT ID: NCT02247947 Completed - Cardiac Arrest Clinical Trials

Proteomics to Identify Prognostic Markers After CPR and to Estimate Neurological Outcome

Start date: September 2014
Phase:
Study type: Observational

Proteomics is used to identify prognostic markers after CPR. Additionally neurological outcome should be estimated by specific protein alterations and affections of pathways.

NCT ID: NCT02224274 Completed - Cardiac Arrest Clinical Trials

Antiplatelet Therapy After Cardiac Arrest

Start date: August 2014
Phase: Phase 4
Study type: Interventional

There is growing evidence that standard dual antiplatelet therapy with acetylsalicylic acid (ASA) and clopidogrel is not as effective in the setting of therapeutic hypothermia after cardiac arrest as in normothermic patients. The reasons for this are probably slower gastrointestinal motility, absorption and liver metabolism required for clopidogrel to take action. Since ticagrelor has faster intestinal absorption and no need for liver metabolism we expect its effect to be good even in patients with therapeutic hypothermia after cardiac arrest. Patients treated with therapeutic hypothermia after cardiac arrest and percutaneous coronary intervention will be randomised into two groups. One will be treated with ASA and clopidogrel and the other with ASA and ticagrelor. Blood samples will be collected before and 2, 4, 12, 22 and 48 hours after P2Y12 inhibitor administration. Platelet function will be measured by VerifyNow P2Y12 assay and by Multiplate ADPTest. Differences between the groups will be analysed. Hypothesis: Antiplatelet therapy with ticagrelor is more effective than therapy with clopidogrel in the comatose survivors of cardiac arrest treated with therapeutic hypothermia and percutaneous coronary intervention (PCI).