Brain Oxygenation During Cardiopulmonary Resuscitation

Cardiac Arrest, Out-Of-Hospital Clinical Trial

Official title:

Brain Oxygenation During Cardiopulmonary Resuscitation - Observational Pilot Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03464123
• Other study ID #: 54/13/03/02/16
• Status: Completed
• Start date: February 24, 2017
• Est. completion date: April 30, 2019

Study information

• Verified date: May 2019
• Source: Helsinki University Central Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study is aimed to assess (a) the incidence of hyperoxia at the point of return of spontaneous circulation (ROSC) and (b) the role of arterial blood oxygen partial pressure to brain oxygenation during out-of-hospital cardiac arrest. 80 adult patients will be recruited in a physician staffed helicopter emergency medical services. Brain regional oxygen saturation and invasive blood pressure are monitored until hospital admission and arterial blood gases are analyzed immediately when the unit arrives to the patient and again at the time of ROSC.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: April 30, 2019
• Est. primary completion date: April 30, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• out-of-hospital cardiac arrest of presumed cardiac origin

• resuscitation will be continued at least 5 minutes (if return of spontaneous circulation not achieved earlier) after arrival of physician team

Exclusion Criteria:

• do-not-attempt-resuscitation (DNAR) order or withdrawal of treatment by prehospital critical care physician

• return of spontaneous circulation achieved before physician-led critical team arrives

• external cause for cardiac arrest (e.g. trauma, suffocation)

• workload too high or environment too dangerous to perform study procedures

Related Conditions & MeSH terms

• Cardiac Arrest, Out-Of-Hospital
• Heart Arrest
• Out-of-Hospital Cardiac Arrest

Intervention

Other:
• Standard cardiopulmonary resuscitation
Standard Advanced Life Support based on guidelines 2015, including mechanical chest compression device

Locations

Country	Name	City	State
Finland	FinnHEMS 10, Emergency Medicine and Services, Helsinki University Hospital	Vantaa

Sponsors (1)

Lead Sponsor	Collaborator
Helsinki University Central Hospital

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Arterial oxygen partial pressure	Arterial oxygen partial pressure at the time of return of spontaneous circulation (ROSC)	5-60 minutes
Secondary	Forehead regional oxygen saturation during resuscitation	Oxygen saturation measured using near-infrared spectroscopy	0-60 minutes