Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line

Carcinoma Clinical Trial

Official title:

Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03288298
• Other study ID #: CEBD-CU-2017-09-23
• Status: Not yet recruiting
• Phase: Early Phase 1
• First received: September 12, 2017
• Last updated: September 18, 2017
• Start date: November 1, 2017
• Est. completion date: April 1, 2019

Study information

• Verified date: September 2017
• Source: Cairo University
• Contact: Safaa M. Baz, Masters
• Phone: 002 01119777824
• Email: drsafaaelbaz[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line.

Description:

This study is conducted to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line. The primary outcome is apoptosis, while the secondary outcome is cell viability.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 4
• Est. completion date: April 1, 2019
• Est. primary completion date: September 1, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Squamous cell carcinoma cell lines (OSCC, TSCC and HNSCC).

• Luteolin 5,7,3',4'-tetrahydroxy-flavone (MeSH term).

• Application of luteolin as a chemotherapeutic drug.

Exclusion Criteria:

• Any cancer cell line other than OSCC, TSCC and HNSCC cell lines.

• Luteolin glycosides.

Related Conditions & MeSH terms

• Carcinoma
• Carcinoma, Squamous Cell
• Tongue Neoplasms

Intervention

Drug:
• luteolin
flavonoid natural extract
• nano-luteolin
nanoparticles of luteolin

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

References & Publications (1)

Ding S, Hu A, Hu Y, Ma J, Weng P, Dai J. Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest. Tumour Biol. 2014 Apr;35(4):3053-60. doi: 10.1007/s13277-013-1396-5. Epub 2013 Nov 28. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	gene expression of Caspase 3 to detect apoptosis	fold-changes	6 hours
Secondary	cell viability	micromolar	6 hours