Investigating Stress-related Mechanisms in the Laboratory and Real World in Individuals With Cannabis Use Disorder

Cannabis Use Disorder Clinical Trial

Official title: Investigating Stress-related Mechanisms in the Laboratory and Real World in Individuals With Cannabis Use Disorder

Status Completed

Clinical Trial Summary

This research project proposes a novel approach to elucidate the biological adaptations associated with Cannabis Use Disorder and to assess whether such adaptations are predictive of higher drug craving in response to both drug cues and stressors in both the laboratory and real-world, and higher relapse risk and drug use in the real world.

Clinical Trial Description

The intent of this study is to recruit 25 treatment-seeking individuals with Cannabis Use Disorder (CUD) and 25 light users (<1 joint/week) to complete three guided imagery conditions (stress, cannabis, neutral) in inpatient research units. During the guided imagery, repeated measurements of subjective (i.e., craving, negative affect), neuroendocrine (i.e., cortisol), and physiological variables (i.e., heart rate variability [HRV]) will be collected. Thereafter, individuals with CUD will begin one-month of drug counseling treatment coupled with surveys delivered via smartphones daily in the morning, evening, and at four random times during the day. ;

Related Conditions & MeSH terms

• Cannabis Use Disorder
• Marijuana Abuse

• NCT number: NCT04116619
• Study type: Observational
• Source: Yale University
• Status: Completed
• Start date: February 1, 2021
• Completion date: February 1, 2022