Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC) — HaVOC  

Cannabis Use Disorder Clinical Trial

Official title: Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized Controlled Trial

Status Completed

Clinical Trial Summary

Cannabis Hyperemesis Syndrome (CHS) has become a well-documented syndrome since 2004 and is expected to increase in prevalence with continuing liberalization of marijuana and recognition of the disease. Regardless of whether the association with heavy cannabis use is recognized, there is well-documented resistance to traditional anti-emetic treatment. Given promising reports of the use of intravenous haloperidol, a randomized controlled trial comparing it to the commonly administered anti-emetic ondansetron will contribute to the management of CHS

Clinical Trial Description

This is a double-blinded, randomized, cross-over clinical trial that will enroll approximately 80 subjects from at least four different research sites. Patients who have been diagnosed with CHS and enrolled in our study will act as their own controls upon their return to the ED for a subsequent bout of CHS for up to 3 visits per subject. Each patient will be allocated in a 1:1:1 fashion into one of three treatment groups: high- or low-dose haloperidol, or ondansetron, with a minimum 7-day washout period between treatments. As CHS tends to be a recurrent syndrome (presumably given the continued use of cannabis despite recommendations to taper and abstain), it is expected that most subjects will return at least once again, and a substantial subset of the study population will complete all three treatment visits during the trial. ;

Related Conditions & MeSH terms

• Cannabis Use Disorder
• Hyperemesis Gravidarum
• Marijuana Abuse

• NCT number: NCT03056482
• Study type: Interventional
• Source: Queen's University
• Status: Completed
• Phase: Phase 4
• Start date: May 21, 2017
• Completion date: July 7, 2019