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Candidiasis clinical trials

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NCT ID: NCT03580733 Recruiting - Clinical trials for ICU Yeast Intra-abdominal Infection

Study Comparing Caspofungin to Placebo for the Treatment of ICU Intra-abdominal Candidiasis

CASPER
Start date: January 1, 2019
Phase: Phase 3
Study type: Interventional

The incidence of intra-abdominal candidiasis is increasing, and it is now the leading indication for antifungal therapy, ahead of candidemia. Prospective randomized trials of antifungal therapy have almost exclusively concerned patients with candidemia and did not include patients with intra-abdominal infections. The aim of this study is to demonstrate that caspofungin antifungal therapy for intra-abdominal candidiasis in ICU patients is associated with lower failure rate compared to placebo.

NCT ID: NCT03538912 Recruiting - Clinical trials for Invasive Candidiasis

Early Discontinuation of Empirical Antifungal Therapy and Biomarkers

SEAT
Start date: June 6, 2018
Phase: N/A
Study type: Interventional

Empirical antifungal therapy (EAT) is frequently prescribed to septic critically ill patients with risk factors for invasive Candida infections (ICI). However, among patients without subsequent proven ICI, antifungal discontinuation is rarely performed, resulting in unnecessary antifungal overuse. The investigators postulate that the use of fungal biomarkers could increase the percentage of early discontinuation of EAT among critically ill patients suspected of ICI, as compared with a standard strategy, without negative impact on day 28-mortality. To test this hypothesis, the investigators designed a randomized controlled open-label parallel-group study.

NCT ID: NCT03450005 Recruiting - Clinical trials for Invasive Candidiases

ECMM Candida Registry - CandiReg

CandiReg
Start date: January 18, 2018
Phase:
Study type: Observational

The objective of the European Confederation of Medical Mycology - ECMM Candida Registry (CandiReg) is to overcome the lack of knowledge on epidemiology, clinical course, and molecular characteristics of invasive infections due to invasive Candida infections and to function as a platform for future studies and in case of outbreaks.

NCT ID: NCT03090334 Recruiting - Abdominal Infection Clinical Trials

A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

This is a multicenter, prospective, open-label, randomized trial. Patients with severe abdominal condition developing severe sepsis or septic shock and receiving broad spectrum antibiotic and antifungal treatment will be randomized (1:1) to: 1. discontinue antifungal treatment based on negative (<80 pg/ml) result of 1,3 beta-d-glucan performed on day 0,3,6 and 10 2. continue antifungal treatment according with attending physician's decision.

NCT ID: NCT03075046 Recruiting - Clinical trials for Candidiasis, Vulvovaginal

Use of 405nm Blue Light Emitting Diode in the Treatment of Women With Vulvovaginal Candidiasis: a Clinical Trial

Start date: April 20, 2017
Phase: N/A
Study type: Interventional

Vulvovaginal candidiasis (CVV) is an infectious process of the female genitourinary tract, an important health issue due to the high incidence and difficulties encountered in the treatment. Therefore, new therapeutic modalities are sought with the capacity to minimize drug side-effects and to reduce recurrent cases. The objective of this stufy is to evaluate the clinical and microbiological response of the 405 nm blue light emitting diode in the treatment of women with vulvovaginal candidiasis and in women with healthy gentourine treatment. A clinical trial was conducted involving 40 women, divided into two groups, the first group consisting of women with a confirmed CVV diagnosis and a second group formed by women with a healthy genitourinary tract, without symptoms and symptoms of the disease. Both groups underwent clinical evaluation and examination with endocervice collection with gynecologist before and after a session of application of the Blue Light Emitting Diode of 405 nm, lasting 4.5 minutes. There will also be an evaluation of the effects of the diary through the questionnaire answered before and after the participants' treatment. It is expected that the 405 nm blue LED will destroy the CVV fungus demonstrated by laboratory examination and also improve the signs and results analyzed by the gynecologist and participants.

NCT ID: NCT03024502 Recruiting - Clinical trials for Vulvovaginal Candidiasis

Patients With Vulvovaginal Candidiasis

EPP-AFG-VVC
Start date: January 30, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The present study aims to evaluate the safety of two mucoadhesive gels containing a propolis standardized extract identified as EPP-AF, with 1 and 2% of propolis. The efficacy studies with both propolis gels will be performed in comparison with clotrimazole cream in patients presenting vulvovaginal candidiasis.

NCT ID: NCT02635438 Recruiting - Clinical trials for Oropharyngeal Candidiasis

A Comparative Clinical Trial to Evaluate the Safety and Clinical Equivalence of Clotrimazole Troche/Lozenges USP, 10mg (Unique Pharmaceutical Laboratories, India) With Clotrimazole Troche 10mg (Roxane Laboratories Inc., USA) in Subjects With Oropharyngeal Candidiasis.

TPC
Start date: December 2016
Phase: Phase 3
Study type: Interventional

The objectives of this study are to compare the efficacy and safety of Clotrimazole troche/ lozenges USP, 10 mg (Unique Pharmaceutical Laboratories, India) vs. Clotrimazole Troche/ Lozenges USP, 10 mg (Roxane Laboratories Inc., USA) in patients with oropharyngeal candidiasis, where this condition has been diagnosed by clinical examination and confirmed by fungal culture

NCT ID: NCT01438216 Recruiting - Candidemia Clinical Trials

Anidulafungin Pharmacokinetics in Intensive Care Unit Patients

ANICK
Start date: September 2011
Phase: N/A
Study type: Observational

The purpose of this study is to determine the pharmacokinetics of anidulafungin in intensive care patients.

NCT ID: NCT01386437 Recruiting - Clinical trials for Invasive Aspergillosis

Natural History of Individuals With Immune System Problems That Lead to Fungal Infections

Start date: November 5, 2012
Phase:
Study type: Observational

Background: - The immune system is made up of special cells, tissues, and organs that fight infections. Problems with this system may lead to frequent, severe, or unusual fungal infections. These infections are often difficult to treat. Researchers want to collect blood and tissue samples from people who have unusual, persistent or severe fungal infections or immune problems that increase the risk of these infections. Objectives: - To collect medical information and samples for a long-term study of people with immune system problems that lead to fungal infections. Eligibility: - People with a history of fungal infections caused by immune system problems. - Parents, children, and siblings of this group. - Healthy volunteers not related to the first two groups. Design: - This long-term study may last for up to 10 years. Those in the study may need to provide new information about every 6 months. The procedures for each person may vary with the particular diagnosis and the extent of fungal infection. Healthy volunteers may have only one or two visits. - At the first visit, those in the study will have a full medical history and physical exam. They will also provide blood. - Research procedures may include the following: - Saliva, urine or stool testing - Mouthwash collection for DNA testing - Collection of cheek cells, nail clippings, or vaginal fluid - Tests of leftover tissue or body fluid from previous medical procedures - Skin or oral mucous membrane biopsy - Collection of white blood cells - Followup visits will involve a physical exam and updated medical history. Blood, saliva, urine, or nail clipping samples may be taken for ongoing studies. Any additional tests or exams required by the study doctors may also be done. - Participants may withdraw from the study pool at any time.

NCT ID: NCT01315925 Recruiting - Clinical trials for Acute Myeloid Leukemia

Pre-hospital Risk Factors for Invasive Fungal Infection

SEIFEM 2010
Start date: January 2010
Phase: N/A
Study type: Observational

SEIFEM 2010 study is a prospective, multicenter registry designed to identify and analyze risk factors for developing an invasive fungal infection in patients with newly diagnosed Acute Myeloid Leukemia, with particular interest on pre-hospital risk factors (i.e. those related to normal activities of daily life, such as occupation, location and type of residence, consume of tobacco, alcohol and others).