Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT05121207 |
| Other study ID # |
JH464519 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
February 28, 2022 |
| Est. completion date |
March 15, 2023 |
Study information
| Verified date |
June 2024 |
| Source |
University Hospitals Coventry and Warwickshire NHS Trust |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Medical imaging commonly involves the use of radiation, such as x-rays, that can give
detailed images of internal structures of the body but can carry a small risk of tissue
damage due to the radiation involved. As such, the number of x-rays and computed tomography
(CT) scans that an individual can have has to be minimised. Methods have recently been
developed that make use of electromagnetic radiation for imaging purposes at terahertz (THz)
frequencies, the region of the spectrum between millimetre wavelengths and infrared.
Terahertz spectroscopic imaging uses low power levels such that adverse effects on tissues
are insignificant and is safe for in vivo imaging of humans [1]. The terahertz region is
between the radio frequency region and the optical region generally associated with lasers.
Both the IEEE RF safety standard and the ANSI Laser safety standard have limits into the
terahertz region. The focus of this project is to investigate THz spectroscopic imaging as a
new and powerful tool for analysing skin properties, termed "THz skinometry". The novelty in
this project lies in tailoring the instrumentation and algorithms of THz scanning to
accurately measure properties of human skin (e.g. hydration levels and skin thickness) in
vivo. The customised non-contact and pressure-controlled contact THz probes developed will be
able to do spectroscopic measurements of skin in vivo at the molecular level. This will be
the first demonstration of in vivo THz imaging of skin globally and will facilitate
quantitative characterisation of skin in a way that has hitherto not been possible and could
lead to a step change in THz technology usage (similar to that currently used in airport
security scanners).
Description:
The SINATRA study is pilot study with a primary aim to explore the feasibility of the trial
methodology. In addition, secondary objectives of the study will investigate if THz light is
able to detect subtle differences in skin hydration and their clinical relevance. Due to the
unprecedented sensitivity of THz light to skin hydration, the investigators will also
investigate if different skin types have a preferential uptake of certain emollients. This
would include dry skin conditions such as eczema, psoriasis and post-operative scars. This
will give us information on how to optimise the types of emollients used in future
development of new moisturisers and sunscreens. This is already under investigation in a
cohort of volunteers with unaffected skin (unpublished pilot study data, University of
Warwick). Additionally, as part of the SINATRA study, the investigators will investigate if
THz imaging is able to detect subclinical (invisible) skin cancer (residual basal cell
carcinoma (BCC)) and enhance the diagnosis of suspected skin cancer (malignant melanoma) in
vivo. Skin cancer is known to produce a localised inflammatory reaction and microscopic
swelling and so the changes in skin hydration may be able to be objectively measured by THz
skinometry.
Terahertz (1012 Hz) pulsed imaging is a new technique with high resolution and has only
emerged recently as a potential new clinical tool for medical imaging. It is a safe imaging
modality as the light is non-ionising - it has a million times lower energy than an x-ray and
thus doesn't have enough energy to cause ionisation. The power levels used in the THz systems
in this study are also very low such that there are no lasting effects. In particular, our in
vivo THz imaging systems have a peak power less than 40mW and average power intensity less
than 4 µW/cm2. Studies by Hough et al [2] have shown that even using peak power 50,000 times
higher and an average intensity 30 times higher does not cause any change in gene expression.
Therefore, power levels used in our THz in vivo imaging systems are safe and have no known
side effects or risks
The SINATRA study will collect preliminary pilot data from participants in a two-arm
feasibility observational study.
1. One arm will consist of 100 patients with known or suspected skin cancer (skin cancer
defined as: incompletely excised BCC with histologically proven radial margin
involvement; biopsy proven BCC, or pigmented lesions suspicious of malignant melanoma).
Images will be taken in the clinic prior to planned skin surgery and later compared to
the formal histology results after the primary (melanoma) or residual (BCC) tumour has
been removed.
2. The second arm will consist of 50 patients with benign dry skin conditions (eczema,
psoriasis, skin grafts, scars etc.) and will compare the water content of their skin
before and after application of a propriety emollients in common usage (e.g. E45®,
Aveeno®, Doublebase®). This will add to the existing dataset that has been recorded from
healthy non-patient volunteers (unpublished data, University of Warwick). This may help
to guide patient-specific emollient selection in the future.
This will add to the knowledge base to define the appearance of skin cancers under THz
skinometry. The spectroscopic findings will not influence the established management that
will have been planned in conjunction with a Consultant Dermatologist or Plastic Surgeon and
the patient.
Study arm 1: The study arm of 50 patients with benign dry skin conditions will undergo a scan
with the THz skinometer and will compare the water content of skin before and after
application of propriety emollients in common usage (e.g. E45®, Aveeno®, Doublebase®).
Participants will have a THz scan of the dry skin area and a control area. Then they will
apply their emollient and wait 10 minutes having another 2 scans of the control area and dry
skin area. Finally there will be another 10 minute wait before having a final scan of the
control area and dry skin area. There are 6 scans in total for this group.
Study arm 2: The arm with 100 patients with known or suspected skin cancer will have a scan
with the THz skinometer in the clinic prior to their planned skin surgery. They will be
scanned on the cancerous area and a control area for a total of 2 scans. Later the results of
the THz scan will be compared to the formal histology results after the primary (melanoma) or
residual (BCC) tumour has been removed.
In vivo THz images from a case study of patients with BCC in 2004 suggested that it should be
possible to detect skin cancer hidden beneath the skin using THz imaging. Spectroscopic
studies by Emma MacPherson and her colleagues in Cambridge in 2006 showed that the
fundamental THz properties of freshly removed (excised) skin cancer tumours are statistically
significantly different from healthy tissue and it is thought that the differences are
primarily due to changes in water content of the tissue. The high sensitivity of THz light to
water also means that the THz signal is strongly attenuated and has a very limited
penetration depth in tissue - thus THz scanning would experience great difficulty in
detecting deep tumours. The penetration depth depends on the signal-to-noise ratio of the THz
imaging system, therefore efforts to improve the signal processing and/or the THz
instrumentation have been made. Since then, EM has been investigating the underlying THz
image contrast mechanisms as well as developing new algorithms and approaches to improve the
accuracy of sample characterisation as well as accelerating THz image data acquisition. This
more recent work is pushing the state-of-the-art in THz in vivo imaging, both in accuracy and
speed. This, crucially, means the investigators are now better equipped to do THz imaging in
vivo studies and the investigators have even been able to account for the pores of skin being
blocked (occluded) by the imaging window for the duration of the THz measurement. This
'occlusion' process means the skin cannot breathe normally and water accumulates in the outer
most layer of skin, the stratum corneum (SC). EM has exploited this phenomenon to pioneer the
use of THz imaging to determine rate of water diffusion within the SC during occlusion. EM
has also been developing in vivo imaging instrumentation techniques and identifying the key
variables and parameters such as contact pressure and occlusion duration. EM's latest results
show that the refractive index of the skin increases both with increasing pressure and
increasing occlusion time. These results will be used to develop the THz skinometer and
accompanying characterization algorithms, within this study. EM's findings show how THz
imaging can be used to measure the hydration profile and water diffusivity of skin and this
is the basis of the theory that will be further developed in the SINATRA study to evaluate
the penetration and durability of emollients and sunscreens in different skin types. The
pilot data collected in the SINATRA trial will be valuable in developing a larger trial
leading to a transformative improvement in prevention and treatment of skin cancer and better
moisturisation strategies for other skin conditions.
