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Immune Checkpoint Blockade Therapy Using 18F-FLT PET/CT

Cancer Clinical Trial

Official title:
Early Assessment of Response to Immune Checkpoint Blockade Therapy Using 18F-FLT PET/CT

Clinical Trial Summary

In the current study, advanced positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance (PET/MR) imaging methods will be used to validate the hypothesis that participants receiving immune checkpoint blockade (ICB) therapy, who ultimately achieve clinical benefit, will show an increase, or "FLARE", in tumor FLT and/or FDG uptake from baseline, as seen after cycle#1 of treatment, and that after 2 cycles of treatment responders will have a decline in FLT and FDG uptake, in comparison to the participants classified as "non-responders".

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04271436
Study type Interventional
Source Washington University School of Medicine
Contact Richard L Wahl, M.D.
Phone 314-362-7100
Email rwahl@wustl.edu
Status Recruiting
Phase Phase 2
Start date April 22, 2021
Completion date January 31, 2025
View Details
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