Cancer Clinical Trial
Official title:
PRevention of INteractions Between Phytotherapies and CancEr Treatments by a SmartphonE/Tablet Automated SurvEy
The use of phytotherapies or specific food or dietary supplement (HFDS) is common among cancer patients. They can also be responsible of clinically relevant interaction with anti-cancer treatments. This study aims at assessing the proportion patients using HFDS which are likely to have an interaction with their anticancer treatments. The data is collected through a smartphone/tablet application. The aim of the study is to demonstrate that clinically significant herb-drug interaction with anticancer treatment could be avoid using these devices.
The use of herbal treatment, also called phytotherapies, or dietary supplements or specific
food (herbs, food or dietary supplements HFDS) is very common and have been evaluated between
30 and 70%, depending on the population and the studies.However, few studies have been made
to evaluate the risk of interaction with oncology treatment in real life. Some interaction
are very well known by both patients and clinicians, like the inhibition of the cytochrome
3A4 by grapefruit or the induction of the CYP3A4 by Saint John's Wort. However, many other
interactions have been demonstrated, like the inhibition of the CYP3A4 by goldenseal extracts
(among many others) although this is frequently used phytotherapy, both over the counter or
"prescribed" by herb specialists.
This study aims at demonstrating that a smartphone or tablet application could be used to
prevent significant interaction between phytotherapy or food or dietary supplements with
anticancer treatments.
The application is used to collect data prospectively that will be analysed for interaction
retrospectively. The interactions between phytotherapy have been classified in 4 categories :
- likely (clinically relevant data in the literature between the herb and the anticancer
treatment either directly or through documented CYP interaction)
- possible (animal model or in vitro data in favor of an interaction)
- unlikely (clinical data or animal model or in vitro data in favor of no interaction)
- unknown (no data available or data from that could not allow a conclusion due to its
poor quality or an ambiguous conclusion) The investigators aim at measuring the
proportion of "likely" herb-drug interaction (or dietary supplement or food) in a
population of patients followed and treated for a cancer, either local or metastatic.
The investigators also aim at characterizing the population, quantifying the proportion of
patients taking HFDS and, to measure the proportion of "possible" herb-drug interaction.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05346796 -
Survivorship Plan HEalth REcord (SPHERE) Implementation Trial
|
N/A | |
Recruiting |
NCT05094804 -
A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents
|
Phase 1/Phase 2 | |
Completed |
NCT04867850 -
Effect of Behavioral Nudges on Serious Illness Conversation Documentation
|
N/A | |
Enrolling by invitation |
NCT04086251 -
Remote Electronic Patient Monitoring in Oncology Patients
|
N/A | |
Completed |
NCT01285037 -
A Study of LY2801653 in Advanced Cancer
|
Phase 1 | |
Completed |
NCT00680992 -
Study of Denosumab in Subjects With Giant Cell Tumor of Bone
|
Phase 2 | |
Completed |
NCT00062842 -
Study of Irinotecan on a Weekly Schedule in Children
|
Phase 1 | |
Active, not recruiting |
NCT04548063 -
Consent Forms in Cancer Research: Examining the Effect of Length on Readability
|
N/A | |
Completed |
NCT04337203 -
Shared Healthcare Actions and Reflections Electronic Systems in Survivorship
|
N/A | |
Recruiting |
NCT04349293 -
Ex-vivo Evaluation of the Reactivity of the Immune Infiltrate of Cancers to Treatments With Monoclonal Antibodies Targeting the Immunomodulatory Pathways
|
N/A | |
Terminated |
NCT02866851 -
Feasibility Study of Monitoring by Web-application on Cytopenia Related to Chemotherapy
|
N/A | |
Active, not recruiting |
NCT05304988 -
Development and Validation of the EFT for Adolescents With Cancer
|
||
Completed |
NCT04448041 -
CRANE Feasibility Study: Nutritional Intervention for Patients Undergoing Cancer Surgery in Low- and Middle-Income Countries
|
||
Completed |
NCT00340522 -
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development
|
||
Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
Active, not recruiting |
NCT03844048 -
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
|
Phase 3 | |
Completed |
NCT03109041 -
Initial Feasibility Study to Treat Resectable Pancreatic Cancer With a Planar LDR Source
|
Phase 1 | |
Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A | |
Terminated |
NCT01441115 -
ECI301 and Radiation for Advanced or Metastatic Cancer
|
Phase 1 | |
Recruiting |
NCT06206785 -
Resting Energy Expenditure in Palliative Cancer Patients
|