Cancer Clinical Trial
Official title:
Phase II Study to Evaluate Postoperative Chemotherapy in High-Grade Appendiceal Adenocarcinoma With Peritoneal Carcinomatosis
The purpose of this study is to find out if postoperative chemotherapy in patients with
high-grade appendix cancer after surgery improves outcomes.
The postoperative chemotherapy will consist of 5-FU (with leucovorin) or capecitabine with
bevacizumab. These drugs are approved for use in people with colon cancer, and they are used
at UCSD for some patients with appendix cancer.
The purpose of this study is to explore the safety and efficacy of the postoperative
chemotherapy treatment on cancer.
This is an observational, single-cohort, prospective study of systemic chemotherapy after
CRS/HIPEC. Subjects will be given twelve months of 5-FU or capecitabine with bevacizumab
starting 4-16 weeks after surgery. CTRI Biostatistics Core personnel will assist in
conducting analyses using the latest version of R (R Foundation for Statistical Computing,
Vienna, Austria. http://www.R-project.org/).
No therapy is included in this study. Subjects have already previously undergone surgery for
their cancer. This study will observe the outcomes of the postoperative chemotherapy
treatment the doctor chooses to treat the subject's cancer.
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