Clinical Trials Logo
  1. Home
  2. Cancer
  3. NCT01022723
  4. Details
NCT01022723 Clinical Trial

Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells

Cancer Clinical Trial

— CTC  

Official title:
Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01022723
Other study ID # CTC_ver2_081109
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date October 2009
Est. completion date December 2018

Study information
Verified date September 2018
Source National Cancer Centre, Singapore
Contact Lanying Wang, Primary
Phone +6564368267
Email nctwly@nccs.com.sg
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To evaluate the efficiency of a microdevice for circulating tumor cells isolation and to correlate the circulating titre with response and progression.

Description:

- Validate the clinical use of a mircofluidic device to capture circulating timor cells from a broad range of tumor types

- Characterize and identify these circulating tumor cells and demostrate cell viability with this capture method

- Apply this technology in clinically relevant settings and correlate to response to treatment and disease progression

- Elucidate predictive and pharmacodynamic biomarkers in the context of early phase trials of novel therapeutics

Recruitment information / eligibility
Status Recruiting
Enrollment 817
Est. completion date December 2018
Est. primary completion date December 2018
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Patients with newly diagnosed metastatic disease planned for palliative chemotherapy

- Tumor types as specified: non smokers with lung adenocarcinoma, undifferentiated EBV-ISH positive nasopharyneal carcinoma, breast cancer, colorectal cancer, prostate cancer, gastric cancer

- Informed consent given for the purposes of blood sampling for this study

- Measurable disease by RECIST criteria of at least 1cm is preferred but not a sine qua non for study accrual

Exclusion Criteria:

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Singapore National Cancer Centre Singapore

Sponsors (3)
Lead Sponsor Collaborator
National Cancer Centre, Singapore National Medical Research Council (NMRC), Singapore, National University, Singapore

Country where clinical trial is conducted

Singapore, 

Outcome
Type Measure Description Time frame Safety issue
Primary The validation of the clinical use of a microfluidic device to capture circulating tumor cells (CTC) from a broad range of tumor types 3 years
Secondary Characteristics and viability of the CTC with this capture method 3 years
Secondary Clinical application of this capture method with the study of CTC titre correlation to treatment outcome 6 years
Secondary Study of predictive and pharmacodynamic biomarkers of the CTC in the context of early phase trials of novel therapeutics 6 years
See also
  Status Clinical Trial Phase
Recruiting NCT05346796 - Survivorship Plan HEalth REcord (SPHERE) Implementation Trial N/A
Recruiting NCT05094804 - A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents Phase 1/Phase 2
Completed NCT04867850 - Effect of Behavioral Nudges on Serious Illness Conversation Documentation N/A
Enrolling by invitation NCT04086251 - Remote Electronic Patient Monitoring in Oncology Patients N/A
Completed NCT01285037 - A Study of LY2801653 in Advanced Cancer Phase 1
Completed NCT00680992 - Study of Denosumab in Subjects With Giant Cell Tumor of Bone Phase 2
Completed NCT00062842 - Study of Irinotecan on a Weekly Schedule in Children Phase 1
Active, not recruiting NCT04548063 - Consent Forms in Cancer Research: Examining the Effect of Length on Readability N/A
Completed NCT04337203 - Shared Healthcare Actions and Reflections Electronic Systems in Survivorship N/A
Recruiting NCT04349293 - Ex-vivo Evaluation of the Reactivity of the Immune Infiltrate of Cancers to Treatments With Monoclonal Antibodies Targeting the Immunomodulatory Pathways N/A
Terminated NCT02866851 - Feasibility Study of Monitoring by Web-application on Cytopenia Related to Chemotherapy N/A
Active, not recruiting NCT05304988 - Development and Validation of the EFT for Adolescents With Cancer
Completed NCT04448041 - CRANE Feasibility Study: Nutritional Intervention for Patients Undergoing Cancer Surgery in Low- and Middle-Income Countries
Completed NCT00340522 - Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development
Recruiting NCT04843891 - Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis. Phase 1
Active, not recruiting NCT03844048 - An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial Phase 3
Completed NCT03167372 - Pilot Comparison of N-of-1 Trials of Light Therapy N/A
Completed NCT03109041 - Initial Feasibility Study to Treat Resectable Pancreatic Cancer With a Planar LDR Source Phase 1
Terminated NCT01441115 - ECI301 and Radiation for Advanced or Metastatic Cancer Phase 1
Recruiting NCT06206785 - Resting Energy Expenditure in Palliative Cancer Patients