Cancer Clinical Trial
Objective: Chemotherapy regimens containing alkylating agents result in primordial follicle
death and premature ovarian failure. Depending on the age and the type/dose of chemotherapy,
some women may continue to menstruate. Our aim was to ascertain the impact of chemotherapy on
ovarian reserve in patients who previously received chemotherapy by response to controlled
ovarian hyper stimulation (COH) and anti-mullerian hormone (AMH) levels. Design: Prospective
study with retrospective controls Materials and Methods: 45 cancer patients underwent
controlled ovarian stimulation for IVF before (30 patients, 30 IVF cycles) or after (15
patients, 30 IVF cycles) chemotherapy. Patients with basal serum FSH >13mIU/mL or E2>70pg/ml
were excluded. AMH was measured on previously stored serum samples from the day of initiation
of the ovarian stimulation. Results: Mean ages and baseline FSH levels of pre- and
postchemotherapy IVF patients were similar (36.8±0.91 vs. 36.3±1). The mean interval from
completion of chemotherapy to IVF was 8.03±1.32 years (range 1-23). Of the 30 IVF cycles in
post-chemotherapy patients, 22 received alkylating agents and 8 did not.
There were no significant differences between the study and control cycles regarding day-2
estradiol (E2), length of stimulation, total gonadotropin dose, and E2 on hCG day (table 2).
Cycle cancellation rate was 20% and 26.67% for pre and post-chemotherapy patients,
respectively. The number of oocytes retrieved and fertilized were significantly higher in
pre-chemotherapy group (p<0.0001). Two clinical pregnancies were achieved in the
postchemotherapy group, one ending in spontaneous abortion and the other in the delivery of a
healthy baby (6.67% clinical pregnancy rate and 3.33% delivery rate per attempted cycle). All
fertilized oocytes in the control group were cryopreserved at 2-pronuclei stage.
Baseline AMH levels were significantly lower in post chemotherapy IVF patients compared to
those who underwent IVF prior to chemotherapy (0.270 ±0.077 vs. 0.84±0.27 ng/ml, p=0.03). In
the pre-chemotherapy group there was a positive correlation between the AMH levels and the
number of oocytes retrieved (r=0.663, p=0.004 ). This correlation was not detected in the
post chemotherapy group (r=0.205).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05346796 -
Survivorship Plan HEalth REcord (SPHERE) Implementation Trial
|
N/A | |
| Recruiting |
NCT05094804 -
A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents
|
Phase 1/Phase 2 | |
| Completed |
NCT04867850 -
Effect of Behavioral Nudges on Serious Illness Conversation Documentation
|
N/A | |
| Enrolling by invitation |
NCT04086251 -
Remote Electronic Patient Monitoring in Oncology Patients
|
N/A | |
| Completed |
NCT01285037 -
A Study of LY2801653 in Advanced Cancer
|
Phase 1 | |
| Completed |
NCT00680992 -
Study of Denosumab in Subjects With Giant Cell Tumor of Bone
|
Phase 2 | |
| Completed |
NCT00062842 -
Study of Irinotecan on a Weekly Schedule in Children
|
Phase 1 | |
| Active, not recruiting |
NCT04548063 -
Consent Forms in Cancer Research: Examining the Effect of Length on Readability
|
N/A | |
| Completed |
NCT04337203 -
Shared Healthcare Actions and Reflections Electronic Systems in Survivorship
|
N/A | |
| Recruiting |
NCT04349293 -
Ex-vivo Evaluation of the Reactivity of the Immune Infiltrate of Cancers to Treatments With Monoclonal Antibodies Targeting the Immunomodulatory Pathways
|
N/A | |
| Terminated |
NCT02866851 -
Feasibility Study of Monitoring by Web-application on Cytopenia Related to Chemotherapy
|
N/A | |
| Active, not recruiting |
NCT05304988 -
Development and Validation of the EFT for Adolescents With Cancer
|
||
| Completed |
NCT04448041 -
CRANE Feasibility Study: Nutritional Intervention for Patients Undergoing Cancer Surgery in Low- and Middle-Income Countries
|
||
| Completed |
NCT00340522 -
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development
|
||
| Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
| Active, not recruiting |
NCT03844048 -
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
|
Phase 3 | |
| Completed |
NCT03109041 -
Initial Feasibility Study to Treat Resectable Pancreatic Cancer With a Planar LDR Source
|
Phase 1 | |
| Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A | |
| Terminated |
NCT01441115 -
ECI301 and Radiation for Advanced or Metastatic Cancer
|
Phase 1 | |
| Recruiting |
NCT06206785 -
Resting Energy Expenditure in Palliative Cancer Patients
|