Thiopurine Methyltransferase Polymorphisms Evaluation

Cancer Clinical Trial

Official title: Evaluation of Thiopurine Methyltransferase Polymorphisms in the Hispanic Population

Status Withdrawn

Clinical Trial Summary

The purpose of the study is to determine the frequency of allelic variants in TPMT in the Hispanic population and to compare the frequency in the Hispanic population with the Caucasian Population.

Clinical Trial Description

Relatively few studies have been performed evaluating the variant allele frequencies in Spanish populations. To date, no studies evaluating the TPMT variant allele frequency in the Hispanic population have been reported. Hispanics are a growing part of the patient population treated in the United States. Characterization of the proportion of patients with variant genotypes in this population is important since Hispanic children represent a significant proportion of children being treated with thiopurines.

A single 3 cc heparinized blood sample will be obtained for TPMT genotyping. The sample will be obtained either simultaneously with a clinical sample, at the time of an otherwise medically indicated intravenous catheter placement or scavenged from excess blood remaining following clinical laboratory testing. ;

Study Design

N/A

Related Conditions & MeSH terms

• Cancer

• NCT number: NCT00166647
• Study type: Observational
• Source: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Status: Withdrawn
• Phase: Phase 4
• Start date: February 2004