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XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation — ENHANCE  

Cancer Clinical Trial

Official title:
A Dose-escalation and Expansion Phase I/IIa Study of XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation (ENHANCE)

Clinical Trial Summary

This is a first-in-human multi-center study which will be conducted in advanced malignant solid tumors patients. The solid tumor type is limited to melanoma, colorectal, non-small-cell lung, and thyroid cancer with positive BRAF V600 mutation. This study is divided into three stages: Phase Ia: a dose-escalation phase of XP-102; Phase Ib: a dose-escalation and sample size expansion phase of XP-102 plus trametinib; Phase IIa: an expansion phase of XP-102 plus trametinib.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05275374
Study type Interventional
Source Xynomic Pharmaceuticals, Inc.
Contact Sophia Paspal, Ph.D.
Phone 610-405-5974
Email Sophia.paspal@xynomicpharma.com
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date December 2024
Completion date December 2026
View Details
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