Cancer Clinical Trial
Official title:
Epidemiological, Immunological, Pathological and Pharmacogenetic Study of Cancers Occuring After Solid Organs Transplants
About 1500 solid organs transplants are performed each year in the Paris agglomeration.
Cancer risk in the transplanted is about three times higher than in a population of the same
age without any organ transplant. Thus cancer is an important problem for organ transplant.
These cancers can be related to many factors :
- Post-transplant cancers are due in part to the non specific immunosuppression, which
leads to oncogenic viruses replication, and then produces virus inducted cancers (as
lymphoma due to EBV virus).
- Post-transplant cancers can also be due to the carcinogenic factors of the
immunosuppressive drugs (as cyclosporine or tacrolimus, which can cause the appearance
of metastases). However, a new type of immunosuppressive drugs (mTOR inhibitors) appear
to have anti-cancer properties.
- Post-transplant cancers which are not virus-inducted can be relied to genetic factors
of the transplanted patient and/or the transplant donor.
There are 4 axes in this study :
- Axis 1 : Epidemiological, clinical and biological study of the incident cancers in
transplanted patients.
- Axis 2 : Qualitative and quantitative immunological study of lymphocyte cells by the
transplanted patient (determine their characteristics when a cancer appears).
- Axis 3 : Pathological and genetic study of the post-transplant cancer cells (see if the
cancer is caused by the donor or the recipient). Creation of a biobank.
- Axis 4 : Pharmacogenetic study of the immunosuppressive drugs (determine the impact of
patient genetic variability on tolerance and efficiency of the immunosuppressive
drugs).
This is an observational and comparative study (2 control patients are recruited for each 1
case patient).
A case patient is a patient who has developed a cancer after his/her transplant.
A control patient is a patient who has not developed a cancer after his/her transplant.
These 2 groups will be matched according to specific inclusion criteria.
;
Observational Model: Case Control, Time Perspective: Prospective
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