Cancer Clinical Trial
Official title:
Phase II Trial of Gemcitabine, Carboplatin, and Bevacizumab in Chemotherapy Naive Patients With Advanced/Metastatic Urothelial Carcinoma
Gemcitabine and carboplatin are two standard chemotherapy drugs used to treat tumors of the
urothelial tract. These drugs do not shrink tumors in all patients and when they do, it is
generally for a limited amount of time. This has led scientists to look for different ways
to treat cancer.
New drugs have been developed to treat cancer that work differently than standard
chemotherapy drugs. One new class of drugs are called 'angiogenesis-inhibitors'. These drugs
attempt to decrease the blood supply to tumors. By doing so, this may limit the tumor's
source of oxygen and nutrients and prevent the tumor from growing. Bevacizumab is an
anti-angiogenic drug.
In some other cancers such as colon cancer and lung cancer, combining bevacizumab with
standard chemotherapy shrinks tumors in a greater proportion of patients and makes patients
live longer than using standard chemotherapy alone. This has never been tested in urothelial
cancer and we do not know if bevacizumab will have the same effects in this disease. The
purpose of this study is to find out what effects, good and/or bad, the combination of
gemcitabine, carboplatin, and bevacizumab has on you and your cancer.
This is a phase II trial of gemcitabine, carboplatin, and bevacizumab in chemotherapy naïve patients with advanced/metastatic transitional cell carcinoma (TCC) of the urothelial tract. ;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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