Effects of Regional Nerve Block on Cancer Recurrence

Cancer Patient Clinical Trial

Official title:

Effects of Regional Nerve Block on Cancer Recurrence

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03134430
• Other study ID #: LFoquan
• Status: Active, not recruiting
• Phase: N/A
• Start date: July 10, 2017
• Est. completion date: May 1, 2023

Study information

• Verified date: May 2018
• Source: The First Affiliated Hospital of Nanchang University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability，but it is still lack of clinical evidence. Our study aims to explore the effects of regional nerve block on cancer recurrence and the mechanism.

Description:

1. To study the effects of TAP block under ultrasound guide on the recurrence of gastric carcinoma, colon cancer, rectal carcinoma and liver cancer and the underlying mechanisms.

2. To clarify the effects of Lateral thoracic nerve block under ultrasound guide on the recurrence of lung cancer and the underlying mechanisms.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 400
• Est. completion date: May 1, 2023
• Est. primary completion date: March 25, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients with primary cancer undergoing elective surgery under general anesthesia

Exclusion Criteria:

• Disagree to participate,drop out,lose track, infectious abdominal wall,abnormal puncture point,coagulation dysfunction,allergy of local anesthetic ,immune disease,cancer metastasis,mental disease, acute and chronic infectious disease or other severe disease.

Related Conditions & MeSH terms

• Cancer Patient
• Recurrence

Intervention

Other:
• Normal saline
Injection of Normal saline around peripheral nerve
• peripheral Nerve block
Injection of local anesthetics around peripheral nerve

Locations

Country	Name	City	State
China	The first affiliated hospital of nanchang university	Nanchang	Jiangxi

Sponsors (1)

Lead Sponsor	Collaborator
Luo Foquan

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the effect of nerve block on the cancer recurrence rate and survival rate postoperation	to trace cancer recurrence after tumor resection with CT scaning and tumor biological maker test for 5 years	up to 5 years after surgery
Secondary	dosage of intraoperative anesthetic	Record the propofol and remifentanil during the operation	intraoperative period
Secondary	the effect of nerve block on the percentage and classification of immunocyte and content of cytokines	percentage and classification of immunocyte will be detected by Use flow cytometry, and cytokines will be detected by ELISA	at 0h, 24h, 48h after nerve block
Secondary	VAS after operation	Assess the visual analogue scale 24,48h after nerve block	at 24h, 48h after nerve block
Secondary	activity after operation	Observe recovery time of gastrointestinal function and off-bed activity after nerve block	up to 2 weeks
Secondary	Hospital stay	Observe length of hospital stay	up to 4 weeks after surgery