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Clinical Trial Details — Status: Terminated

Administrative data

NCT number NCT03682367
Other study ID # 1166778
Secondary ID
Status Terminated
Phase Phase 3
First received
Last updated
Start date December 1, 2018
Est. completion date April 6, 2020

Study information

Verified date July 2021
Source University of California, Davis
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Patients undergoing head and neck cancer surgery often have a lot of pain after surgery, which can lead to a need for a lot of narcotic pain medication. These medications can have many side effects that can make recovery more difficult including nausea, vomiting, dizziness, being overly sleepy, itchiness, inability to urinate, confusion, inability to have a bowel movement, longer time before being able to start walking. These side effects can make the hospital stay longer. The use of gabapentin, which is a non narcotic pain medication that focuses on nerve pain, has been used in smaller head and neck surgeries including removal of tonsils, sinus surgery, thyroid surgery. Studies in patients needing orthopedic or OB/Gyn surgery have shown improved pain control with gabapentin. Potential benefits to future patients include improved pain control, less narcotic associated side effects and faster functional recovery.


Description:

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Study Design


Intervention

Drug:
Gabapentin
Use of Gabapentin peri- and post-operatively.
Placebo - Concentrate
Use of sugar-free Placebo peri- and post-operatively.

Locations

Country Name City State
United States UC Davis Medical Center Sacramento California

Sponsors (1)

Lead Sponsor Collaborator
University of California, Davis

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Average Morphine Equivalent Units Determine the difference in average morphine equivalent units between experimental and control group. Perioperative.
Primary Average Morphine Equivalent Units Determine the difference in average morphine equivalent units between experimental and control group. 1 week post-operation.
Primary Average Morphine Equivalent Units Determine the difference in average morphine equivalent units between experimental and control group. 30 days post-operation.
Secondary Pain Score (10 Point VAS) Determine average change of inpatient Pain Score Visual Analog Scale (VAS) on a standardized 1 (no pain) to 10 (highest level of pain) scale between experimental and control groups. Perioperative, 1 week post-operation, 1 week post-discharge, and 30 days post-operation.
Secondary Post-operative Complications Incidence of postoperative complications between experimental and control group. 30 days post-operation.
Secondary Narcotics-related Complications Incidence of narcotics-related complications between experimental and control group. 30 days post-operation.
Secondary Inpatient Length of Stay Determine the difference of average inpatient length of stay between experimental and control group. 1 week post-operation.
Secondary Inpatient Cost Determine the difference of average inpatient cost between experimental and control group. 1 week post-operation.
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