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A Phase Ib Trial of Concurrent Cetuximab (ERBITUX®) and Intensity Modulated Radiotherapy (IMRT) With Ipilimumab (YERVOY®) in Locally Advanced Head and Neck Cancer

Cancer of Head and Neck Clinical Trial

Official title:
A Phase Ib Trial of Concurrent Cetuximab (ERBITUX®) and Intensity Modulated Radiotherapy (IMRT) With Ipilimumab (YERVOY®) in Locally Advanced Head and Neck Cancer

Clinical Trial Summary

This clinical trial is aimed to establish a recommended starting dose of ipilimumab for a future efficacy trial when used in combination with intensity modulated radiation therapy (IMRT) and cetuximab.

Clinical Trial Description

The investigators proposed to integrate anti-CTLA-4 specific mAb, ipilimumab, into a standard regimen of cetuximab plus RT (70-74.0 Gy) in a dose finding, phase I trial, to inform the design of a future phase II clinical trial which would determine clinical efficacy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01860430
Study type Interventional
Source University of Pittsburgh
Contact
Status Active, not recruiting
Phase Phase 1
Start date April 2013
Completion date March 2018
View Details
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