Optimization of MRI for Radiation Therapy

Cancer Liver Clinical Trial

Official title:

Optimization of MRI for Radiation Therapy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02045381
• Other study ID #: UMCC 2012.113
• Secondary ID: HUM00068061
• Status: Recruiting
• Start date: March 14, 2013
• Est. completion date: October 2024

Study information

• Verified date: April 2024
• Source: University of Michigan Rogel Cancer Center
• Contact: Shruti Jolly, MD
• Phone: 734-936-4300
• Email: shrutij[@]umich.edu
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 432
• Est. completion date: October 2024
• Est. primary completion date: October 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients =18 years of age
• A working diagnosis of malignancy in the liver, brain, H&N, or pelvis
• A plan to treat with radiotherapy

Exclusion Criteria:

• Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.

Related Conditions & MeSH terms

• Cancer Brain
• Cancer Head &Neck
• Cancer Liver
• Cancer Pelvis

Intervention

Procedure:
• MRI Group
A single research MRI

Locations

Country	Name	City	State
United States	Univeristy of Michigan	Ann Arbor	Michigan

Sponsors (1)

Lead Sponsor	Collaborator
University of Michigan Rogel Cancer Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of participants with MRI images suitable for analyses	Patients will be off protocol immediately after the single MRI scan. Comparative treatment planning will occur off-line and will not be used for patient care.	Day One