A Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury

Burns Clinical Trial

— MIPA  

Official title:

A Single-centre Prospective Observational Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04500197
• Other study ID #: L2015126
• Status: Completed
• Start date: November 12, 2018
• Est. completion date: September 15, 2020

Study information

• Verified date: October 2020
• Source: Maasstad Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The main objective of our study is to focus on the efficiency of standard fluid resuscitation in promoting tissue perfusion in severe burns patients (>15% TBSA). The incidence of microcirculatory perfusion alterations, according to a predefined arbitrary cut off value, in patients with severe burns injury (>15%TBSA) will be assessed during standard resuscitation in the first 24 hours.

Secondary objectives are to assess differences in microcirculatory perfusion alterations between early (<12 hours post burn injury) and late standard resuscitation (>12 hours post burn injury) with addition of albumin to the regime.

And to measure several biomarkers of glycocalyx shedding, oxidative stress and inflammation.

Description:

Rationale: There are valid concerns that resuscitation in burns shock is inadequate. A tendency to over resuscitate patients seem to exist. Current guidelines were developed 35 years ago and clinical burn resuscitation has not advanced significantly, despite ongoing research. The main goal of resuscitation is achieving organ perfusion and tissue oxygenation. Inadequate fluid resuscitation of severe acute burns may result in hypovolemic shock and death. Excessive fluid resuscitation may result in fluid overload, lung edema, intra-abdominal hypertension, abdominal compartment syndrome and burn depth conversion with increased requirement for escharotomies, fasciotomies and skin grafting. Monitoring of adequacy of resuscitation in burns patients has always been guided by systemic hemodynamic variables (macro circulation) like blood pressure, heart rate, stroke volume and urinary output, being urine output the major indicator of successful resuscitation. Whether these end points are successful in achieving adequate perfusion and oxygen transport to the tissues is unknown and relies on the assumption that there is a hemodynamic coherence between the macro and microcirculation whereby improving the macro circulation causes a parallel improvement in the microcirculation Objective: The main objective of our study is to focus on the efficacy of standard fluid resuscitation in promoting tissue perfusion.

Study design: Single-center, prospective, observational clinical study in the Maasstad Hospital.

Study population: All adult patients who are admitted to the Intensive Care Unit with severe burns over 15%TBSA and resuscitated with the standard resuscitation protocol will be included.

Main study parameters/endpoints: Measurement of sublingual microcirculation with vessel density and flow parameters. Also skin perfusion maps (Laser Speckle Imaging) will be recorded. Blood and urine samples will also be used for measuring glycocalyx shedding products.

Nature and extent of the burden and risks associated with participation, benefit and group relatedness:

Microcirculation assessment and laser speckle imaging are non-invasive procedures, and there are negligible risks. Blood tests will be used for measuring glycocalyx shedding products, this is an invasive procedure which may increase the risk of contamination, patient discomfort and in some extreme cases blood sample collection may be a burden on patient haemoglobin levels which is prone to decrease in critical patients. Assessment is essential for determining whether action is required to change our existing resuscitation regime for critically ill burned patients. If the results show that the current resuscitation regime is suboptimal, then motivation for changing the existing practice can lead to improved clinical care and a reduction in over- or under resuscitation in the ICU environment with its potential harmful effects.

The risks associated with participation can be considered negligible and the burden can be considered minimal in this observational study. The patients taking part in this study will have no direct benefit.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: September 15, 2020
• Est. primary completion date: September 15, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. ICU admission with a severe burn injuries of =15% TBSA

2. = 18 years of age

3. Receiving standard resuscitation protocol for severe burn injury

4. Post burn time up to a maximum of 24 hours

Exclusion Criteria:

1. Informed consent not obtained

2. (suspected) generalised infection

3. Other traumatic injury, which is supposed to generate a systemic inflammatory response eg severe fractures, or other types of shock as a result of massive bleeding

4. Patients unlikely to survive >24 hours

5. Decision not to initiate treatment

Related Conditions & MeSH terms

• Burns
• Microcirculation
• Resuscitation

Locations

Country	Name	City	State
Netherlands	Maasstad Hospital	Rotterdam	Zuid Nederland

Sponsors (1)

Lead Sponsor	Collaborator
Maasstad Hospital

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of microcirculatory perfusion alterations in severe burns patients during standard fluid resuscitation.	The main objective of our study is to measure standard microcirculatory perfusion parameters during standard resuscitation at different time points after a severe burn injury. These perfusion parameters are total vessel density (TVD), proportion of perfused vessels (PPV), functional capillary density (FCD) and focus depth.	Changes in perfusion parameters will be measured on admission (time zero, T=0), four hours after admission (T=4), eight hours after admission (T=8), twelve hours after admission (T=12) and twenty-four hours after admission (T=24
Secondary	Microcirculatory perfusion alterations after administration of albumin.	Secondary objectives are to measure changes in standard microcirculatory parameters before and after administration of albumin. Albumin will be administered 12 hours after admission of the patient.	Changes in microcirculatory perfusion parameters will be measured directly after administration of albumin. This will be 12 hours after starting fluid resuscitation.