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The Relationship Between Cadaveric Allograft Skin and HLA-Sensitivity in Burn Patients

Burns Clinical Trial

Official title:
The Relationship Between Cadaveric Allograft Skin and Human-leukocyte Antigens (HLA)-Sensitivity in Burn Patients

Clinical Trial Summary

The purpose of this research study is to look at how the body's immune system reacts to temporary skin grafts from deceased donors.

Clinical Trial Description

Some burns will heal best with the use of temporary skin grafts from cadavers before covering the burns with grafts of the patient's own skin. This is the usual care for these types of burn injuries recommended by burn surgeons. This skin is applied in the operating room and removed after several days. During that time, the body's immune system will make antibodies to the skin. Normally, these antibodies are harmless. However, extra antibodies can make it difficult to find donors for transplants. The results of this study will be used to better understand how to treat a subset of burn patients with very severe burns in a way that allows them to receive tissue transplants (e.g. face transplants, hand transplants). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04162639
Study type Interventional
Source Virginia Commonwealth University
Contact
Status Withdrawn
Phase Phase 4
Start date February 2021
Completion date February 2023
View Details
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