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Burns clinical trials

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NCT ID: NCT06371885 Active, not recruiting - Clinical trials for Carpal Tunnel Syndrome

Shock Wave on Pillar Pain After Carpal Tunnel Release in Hand Burn

Start date: August 10, 2023
Phase: N/A
Study type: Interventional

"In burn cases, the reported causes of CTS are increased volume of carpal tunnel content due to edema and synovitis, wrist hyperextension, tight dressing, fibrosis, and direct burn to the nerve. There are two types of pain that occur in the palm of the hand after carpal tunnel surgery: incisional pain and pillar pain. The incision pain typically only lasts for a few days or weeks after surgery, while the pillar pain occurs on the sides of the incision in the thicker parts of the palm, called the thenar and hypothenar eminences. This is where the transverse ligament attaches to the carpal bones, forming the carpal tunnel. So, in this study we will find out if shock wave therapy has therapeutic effect on pillar pain after carpal tunnel release in hand burn.

NCT ID: NCT06223269 Active, not recruiting - Wound Heal Clinical Trials

Safety and Efficacy of realSKIN® to Provide Complete Wound Closure of Burn Wounds as an Alternative to Autografting

Start date: January 10, 2024
Phase: Phase 3
Study type: Interventional

To evaluate the safety and efficacy of realSKIN® to provide complete wound closure of mixed-depth, full-thickness burn wounds as an alternative treatment to autografting.

NCT ID: NCT05977595 Active, not recruiting - Hand Burn Clinical Trials

Cosmetic and Functional Sequelae in Hand Burns.

AdipoSCAR
Start date: January 1, 2019
Phase:
Study type: Observational

Although it represents a small percentage of the body surface, the hand is the most exposed part of the body after the face and neck and is one of the area's most frequently involved in burns. It has a social function, but above all, a functionnal one. An optimized reconstruction of this area after the burn allow the patient to recover the best possible function and increase his chances of returning to professional activity and daily life. Advances in burn treatment, such as improved resuscitation management, rapid excision of burns, skin grafting, regular dressings, and improved metabolic support, have reduced the morbidity and mortality of severe burns. However, significant challenges remain. The hand is the most frequently involved area in burns and is affected in 90% of severe burns. Hand burns requiring releasing incisions are circular, deep burns and represent a significant functional challenge. In the acute setting, current treatment options must prevent complications associated with disruption of the skin's protective function. In the longer term, these treatments should allow the regeneration of fully functional skin. However, some sequelae may persist in the form of sensory deficits, residual pain, retractile scars hindering function in this highly mobile area, or even aesthetic sequelae. The aim of our study was to perform a descriptive analysis of the aesthetic and functional sequelae related to hand burns that required acute realeasing incisions using objective and subjective tools available in the medical records (demographic, clinical and follow-up data in the context of routine care). This retrospective, non-interventional, data-driven study would provide an overview of the sequelae of hand burns with current therapies.

NCT ID: NCT05766917 Active, not recruiting - Burns Clinical Trials

Peer Education on Core Health Outcomes Specific for Burn Patients

Start date: March 15, 2023
Phase: N/A
Study type: Interventional

Evaluate the Effectiveness of Peer Education on Core Health Outcomes Specific for Burn Patients

NCT ID: NCT05517902 Active, not recruiting - Burns Clinical Trials

StrataGraft Safety, Tolerability and Efficacy in Pediatric Subjects

StrataSTEPS
Start date: April 28, 2023
Phase: Phase 3
Study type: Interventional

Autografting is a surgical procedure to transplant healthy skin (donor skin) from another part of the participant's own body (donor site) to the burned part. Autografting is the usual treatment for DPT burns. It works to close the wound, but can cause other problems: - Donor sites are painful, can become infected or scarred, or can even become full thickness (FT) wounds themselves - Treatment problems can require more grafting - Additional surgery increases the risk of medical problems caused by the treatment Stratatech is trying to find a safe and effective alternative to autografting to promote the healing of severe burns. The purpose of this study is to evaluate whether StrataGraft treatment eliminates or reduces the need for autografting and promotes wound closure in a pediatric population with thermal burns that contain intact dermal elements and for which autografting is clinically indicated (DPT burns). Participants will be enrolled into one of two age-based cohorts: 2 to < 12 years and 12 to ≤ 17 years to receive a single application of StrataGraft, in up to 3 non-contiguous DPT burn areas located on the same extremity or plane of the torso. The study will last for approximately 2.5 years.

NCT ID: NCT05341427 Active, not recruiting - Burn Wound Clinical Trials

DEVELOPMENT OF A CLINICAL PREDICTION RULES TO IDENTIFY EFFICACY OF PULSED ELECTROMAGNETIC THERAPY ON BURN WOUND HEALING

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate whether patients' age, total burned surface area, wound stage and wound depth determine wound healing response to pulsed electromagnetic therapy in burn patients

NCT ID: NCT05212441 Active, not recruiting - Burns Clinical Trials

ADJUNCTIVE EFFECT OF LIGHT EMITTING DIODE ON HAND GRIP STRENGTH IN BURN PATIENTS

Start date: February 25, 2022
Phase: N/A
Study type: Interventional

This study will be done to evaluate effect of applying LED before hand exercise on hand grip strength. Sixty male patients with subacute partial thickness burn of hand will be randomly allocated into two equal groups of 30 patients. The following equipment and tools will be used Measurement equipments: - For total active motion of fingers (TAM): Goniometer. - For hand grip strength: Hand grip dynamometer. Therapeutic equipment: Light emitting diode therapy (LED) device.

NCT ID: NCT04896346 Active, not recruiting - Scar Clinical Trials

Scarring in Stratagraft-treated vs. Autograft-treated Burn Wounds: a Clinical and Histological Investigation

Start date: February 9, 2022
Phase:
Study type: Observational

The purpose of this study is to describe and better understand the scars of subjects that have been treated with Stratagraft tissue vs autograft.

NCT ID: NCT04894500 Active, not recruiting - Inflammation Clinical Trials

ICIS in Burn Patients Compared to Other Inflammatory Markers

ICARUS
Start date: April 1, 2021
Phase:
Study type: Observational

The current markers of inflammation that govern antibiotic treatment have their significant limitations, especially in patients with burns. According to previously published data, the newly proposed marker of infectious inflammation, the Intensive Care Infection Score (ICIS), appears to be a suitable diagnostic tool in distinguishing between inflammation of infectious and non-infectious origin in these patients. The other advantage is its low price. This study aims to compare ICIS with other used indicators of inflammation in patients with burns both children and adults.

NCT ID: NCT04890574 Active, not recruiting - Burns Clinical Trials

CellMist™ Autologous Cells to Treat Deep Second-Degree Burns

CELLMIST1
Start date: May 26, 2021
Phase: Phase 1
Study type: Interventional

The overall purpose of this study is to evaluate the safety of the CellMist™ System in the treatment of deep second degree burns (II°B) in a prospective, multicenter, feasibility pilot study.