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Burns clinical trials

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NCT ID: NCT03520816 Completed - Burns Clinical Trials

The Effect of Early Physiotherapy on Biochemical Parameters in Major Burn Patients: A Burn Center's Experience

Start date: October 1, 2016
Phase: N/A
Study type: Interventional

Background: This study planned to investigate the effect of early physiotherapy on biochemical parameters in major burn patients. Methods: Ten women (50%) and 10 men (50%) aged 21-47 years old were included in our study. Participants were divided into two groups: one group was the treatment group and the other was the control group. In the treatment group, patients were admitted to the physiotherapy programme from the first day they have been hospitalised, in addition to their routine treatment (medical, surgery, etc.), for 4 days per week. It consisted of parameters such as early mobilisation and ambulatory training, chest physiotherapy, and both active and passive normal joint movement exercises. The days of treatment were determined as Tuesday, Wednesday, Thursday and Friday. Patients could not be treated on a Monday because that was surgery day. The control group consisted of patients who could not receive physiotherapy due to various reasons. All patients included in the study were evaluated weekly for 6 weeks after admission to the hospital. Parameters such as demographic information, characteristics of burn injury, C-reactive protein, fibronectin, transferrin and prealbumin were evaluated.

NCT ID: NCT03513406 Completed - Burns Clinical Trials

Comparison of Reversal of Neuromuscular Blockade With Sugammadex Versus Neostigmine Plus Glycopyrolate in Patients Undergoing Burn Surgery

Start date: March 15, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to learn if there is a difference in recovery time when using sugammadex versus neostigmine. The researchers also hope to add further knowledge and data to the safety of using sugammadex in burn patients who are hypermetabolic.

NCT ID: NCT03498846 Recruiting - Corneal Burn Clinical Trials

Modified Corneal EA With Middle LKP for Severe Corneal Burn

Start date: May 10, 2018
Phase: N/A
Study type: Interventional

The purpose of this pilot study is to explore whether modified corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular surface reconstruction in patients with severe corneal burn.

NCT ID: NCT03475654 Recruiting - Burns Clinical Trials

A Prospective Trial of Virtual Home Rehabilitation After Burn Injury

Start date: February 8, 2018
Phase: N/A
Study type: Interventional

The overarching goal for this prospective randomized controlled trial (PRCT) is to determine whether a virtual-environment, home-rehabilitation program improves functional outcomes for individuals after a burn injury. Specifically, this study will test the efficacy of a technology-assisted rehabilitation program against current standard of home therapy.

NCT ID: NCT03433664 Completed - Burns Scarring Clinical Trials

Carbon Dioxide Laser Treatment in Burn-related Scarring

Start date: February 20, 2014
Phase: N/A
Study type: Interventional

This study evaluates the effect effect of ablative fractional CO2 laser (AFCO2L) on burns scar appearance and dermal architecture at 6 weeks and up to 3-years post-treatment. Half of the scar will receive AFCO2L and half the scar will receive standard care.

NCT ID: NCT03421769 Completed - Ocular Burns Clinical Trials

Corneal Epithelial Autograft With Middle Lamellar Keratoplasty for Severe Ocular Burns

Start date: February 9, 2018
Phase: N/A
Study type: Interventional

The purpose of this pilot study is to explore whether corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular surface reconstruction in patients with severe ocular burns.

NCT ID: NCT03393130 Not yet recruiting - Critical Illness Clinical Trials

Perioperative Research Into Memory, Genomics in the Intensive Therapy Unit: Alzheimer's

PRIMoGenITA
Start date: February 1, 2018
Phase: N/A
Study type: Observational

The current central dogma of long-term cognitive impairment after intensive care admission suggests an underlying neuroinflammatory dysregulation affecting neuronal function. This pathological process has not been fully elucidated and there has been little research into its genetic associations. Alzheimer's disease (AD) causes cognitive impairment through a process of abnormal beta amyloid deposition and neuronal death through localised activation of the innate immune system. It is the most prevalent disease affecting cognition. The Apolipoprotein E (APOE) gene is implicated in the progression of late-onset Alzheimer's disease and is a recognised neuroinflammatory modulator. It is possible that young individuals exposed to high levels of inflammation may experience an acceleration of this process. This study sets out to look for an association between APOE-∈4 possession and poor cognitive outcome after a major burn injury and intensive care admission.

NCT ID: NCT03352297 Completed - Burn Scar Clinical Trials

Nanofat in Post Burn Scars on the Face

Start date: January 1, 2016
Phase: N/A
Study type: Interventional

Quasi-Experimental Study: Unfiltered Nanofat Injected into Postburn Facial Scars Number of Patients: 48 Outcome Assessed on POSAS And with Imaje J Scanning Preop And Postop Statistical Comparison of Scar Done

NCT ID: NCT03343353 Not yet recruiting - Burn Injury Clinical Trials

Therapy by Led (Light Emission Diode) in Cutaneous Lesion: in Vivo

Start date: February 19, 2018
Phase: N/A
Study type: Interventional

Light Emitting Diode (LED) therapy has been investigated in burns and skin ulcers, as it has a bactericidal effect and promotes tissue repair. This study aims to evaluate LED therapy at different wavelengths in the healing process of graft donor area in adult burn victims.

NCT ID: NCT03340116 Withdrawn - Burns Clinical Trials

Measurement of Blood Volume Loss During Burn Surgery

Start date: January 2020
Phase:
Study type: Observational

Burn surgery is associated with significant reductions in hematocrit. However, it is unclear whether these reductions are the result of hemodilution from non-red cell containing intraoperative transfusions or from loss of red blood cells. The investigators will be using the Daxor Blood Volume Analyzer (BVA-100), an FDA approved instrument that can measure total blood volume, plasma volume, and RBC volume using the indicator dilution technique. By comparing pre-operative measurements of blood volume, plasma volume, and RBC volume to that of post-operative measurements after burn surgery, the investigators can determine the primary cause of the reduction in hematocrit associated with burn surgery. The investigators hypothesize that these reductions in hematocrit are primarily the result of hemodilution rather than blood loss and that there will be a statistically significant difference in measured plasma volume from the pre-operative group to the post-operative group.