Bullous Emphysema Clinical Trial
Official title:
A Feasibility and Safety Study of Bronchoscopic Intrabullous Autologous Blood Instillation for the Treatment of Severe Bullous Emphysema (BIABI Study)
Patients with large bullae (large empty air sacs in the lung) may benefit from bullectomy
(surgery to resect these bullae), however this is a major surgery with significant potential
morbidity and long hospital stays. Many patients are not well enough to have this surgery,
or may not wish to have it. A less invasive means of attempting to shrink the size of the
bullae is to directly inject the patients' own blood into the bullae (we believe that this
can lead to an inflammatory reaction leading to gradual scarring and volume loss). This can
be performed bronchoscopically in a 20-30 minute procedure using conscious sedation
(avoiding general anaesthesia).
The aim of this study is to assess the effects on lung function, quality of life measures,
functional measures and CT measured lung volumes of bronchoscopic intrabullous blood
instillation in patients with bullous emphysema.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment