A Study of Famitinib Malate in HER2-negative Metastatic Breast Cancer

Breast Neoplasms Clinical Trial

Official title:

A Single-Institutional, Phase II, Open-label, Single Arm Trial of Famitinib Malate in in HER2-negative Metastatic Breast Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01653574
• Other study ID #: Fudan BR2012-10
• Status: Completed
• Phase: Phase 2
• First received: July 10, 2012
• Last updated: December 1, 2013
• Start date: May 2012
• Est. completion date: November 2013

Study information

• Verified date: March 2013
• Source: Fudan University
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The hypothesis of this clinical research study is to discover if the study drug Famitinib Malate can shrink or slow the growth of pretreated HER2-negative metastatic breast cancer.

Description:

Famitinib Malate is a tyrosine kinase inhibitor mainly targeting vascular endothelial growth factor receptor 2(VEGFR2), and its anti-angiogenesis effect has been viewed in preclinical tests. The investigators' phase I study has shown that the drug's toxicity is manageable and the recommended phase II dose is 25 mg. The hypothesis of this clinical research study is to discover if the study drug Famitinib Malate can shrink or slow the growth of pretreated HER2-negative breast cancer. The safety of Famitinib Malate will also be studied. Patients physical state, symptoms, changes in the size of the tumor, and laboratory findings obtained while on-study will help the research team decide if Famitinib Malate is safe and effective in pretreated HER2-negative metastatic breast cancer patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: November 2013
• Est. primary completion date: November 2013
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

?= 18 and = 70 years of age.

• ECOG performance status of 0-1.

• Women diagnosed with HER2-negative breast cancer. HER2- is defined as 0 or 1+ staining on immunohistochemistry or FISH/CISH negative for gene amplification.

• Metastatic breast cancer, confirmed by histological analysis.

• Have failed from the last chemotherapy regimen, but experienced at most 2 regimens in the relapsed or metastatic setting. Pretreated anthracycline, taxanes and capecitabine (any rational reason for no use of capecitabine is acceptable) are mandatory.

• Have failed from at least 1 endocrine therapy, if HR positive.

• Duration from the last therapy (chemotherapy, radiotherapy, target therapy and operation) is more than 4 weeks (Duration for nitroso or mitomycin is 6 weeks).

• Have at least one extracranial measurable site of disease according to RECIST 1.1 criteria that has not been previously irradiated.

• Life expectancy of more than 3 months.

• If the patients have brain or meninges metastases, the lesions must have been controlled at least 8 weeks.

• Adequate hepatic, renal, heart, and hematologic functions (hemoglobin = 90g/L, neutrophils = 1.5×10^9/L, platelets = 80×10^9/L , ALT = 2.5 x upper limit of normal (ULN), AST = 2.5 x ULN, serum bilirubin = 1.5 x ULN, serum creatine = 1.5 x ULN, creatinine clearance rate = 50ml/min, PT, APTT = 1.5 x ULN), serum cholesterol = 1.25 x ULN, serum glycerin trilaurate = 2.0 x ULN, LVEF = lower limit of normal (LLN).

• Negative serum or urine pregnancy test taken in all women within 7 days before inclusion. Sexually active women of childbearing potential must use a medically acceptable form of contraception (which include oral contraception, injectable or implantable methods, intrauterine devices, or properly used barrier contraception) from the beginning of the study to 8 weeks after the last dose of the investigated drug. A woman of childbearing potential is defined as one who is biologically capable of becoming pregnant. This includes women who are using contraceptives or whose sexual partners are either sterile or using contraceptives.

• Written informed consent prior to study specific screening procedures, with the understanding that the patient has the right to withdraw from the study at any time without prejudice.

Exclusion Criteria:

• Pregnant or lactating women.

• Uncontrolled hypertension with mono-drug therapy (>140/90 mm Hg);ischemia of the myocardium (= grade 2) or myocardial infarction;arrhythmia(= grade 2, QTcF > 480ms for female patients) or New York Heart Association Class III/IV.

• Abnormal thyroid function history with drug intervention.

• Any factors that influence the usage of oral administration.

• The cumulative doses of doxorubicin and epirubicin before inclusion have surpassed 300 mg/m2 and 600 mg/m2, respectively.

• Brain or meningeal metastases.

• Receiving the therapy of thrombolysis or anticoagulation.

• Unhealed wound or bone fracture.

• Urine protein =++ and confirmed >1.0 g by the 24h quantity.

• Previous or present history of pulmonary fibrosis,interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonitis or greatly-impaired pulmonary function.

• Disability of serious uncontrolled intercurrence infection.

• The active HBV or HCV infection or HBV DNA =10^4/ml.

• Acquired or inherent immunodeficiency; HIV infection; organ transplantation history.

• Abuse of alcohol or drugs.

• Have received prior treatment with a VEGFR TKI (Bevacizumab is permitted).

• History of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix.

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Breast Neoplasms

Intervention

Drug:
• Famitinib Malate
The starting dose of Famitinib Malate will be 25 mg/d. Two dose reductions will be allowed to 20 and then 15 mg/d.

Locations

Country	Name	City	State
China	Fudan University Cancer Hospital	Shanghai	Shanghai

Sponsors (2)

Lead Sponsor	Collaborator
Fudan University	Jiangsu HengRui Medicine Co., Ltd.

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ORR (Objective response rate)		8 Weeks	Yes
Secondary	PFS(Progression free survival)		8 Weeks	Yes
Secondary	OS (Overall survival)		8 Weeks	Yes
Secondary	CBR(Clinical benefit rate)		8 Weeks	Yes
Secondary	QoL (Quality of life)		8 Weeks	Yes
Secondary	Number of adverse events		8 Weeks	Yes