BRCA1 Gene Mutation Clinical Trial
Official title:
A Phase II Study of Talazoparib (BMN 673) in Patients With Homologous Recombination Repair Deficiency Positive Stage IV Squamous Cell Lung Cancer (Lung-Map Sub-Study)
| Verified date | June 2021 |
| Source | Southwest Oncology Group |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
This phase II trial studies how well talazoparib works in treating patients with homologous recombination repair deficiency (HRRD) positive stage IV squamous cell lung cancer that has come back after previous treatment. Talazoparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
| Status | Completed |
| Enrollment | 51 |
| Est. completion date | April 16, 2021 |
| Est. primary completion date | January 10, 2021 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | N/A and older |
| Eligibility | Inclusion Criteria: - Patients must meet all SCREENING/PRE-SCREENING and SUB-STUDY REGISTRATION COMMON ELIGIBILITY CRITERIA as specified in S1400: Phase II/III Biomarker-Driven Master Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map) - Patients must be assigned to S1400G; S1400G biomarker eligibility defined as homologous recombination repair deficiency (HRRD) positive is as follows - Biomarker-positive group - HRRD by FMI - Homologous recombination repair deficiency by Foundation Medicine Inc., criteria - Alteration type - Truncating mutation, frameshift deletions, indels missense and nonsense mutations predicted to have functional consequence in any of the specified genes - Eligible alteration - Mutation in any one of the following critical HRR pathway genes: ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCF, FANCM, NBN (NBS1), PALB2, RAD51, RAD51B (RAD51L1), RAD54L, RPA1 - Patients must not have had prior exposure to any agent with a PARP inhibitor (e.g., veliparib, olaparib, rucaparib, niraparib, talazoparib [BMN 673]) as its primary pharmacology - Patients must have achieved stable disease, a partial response, or a complete response at their first disease assessment after initiating first-line platinum-based chemotherapy; patients determined to have progressed (in the opinion of the treating physician) at their first disease assessment are not eligible - Patients may not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of talazoparib (BMN 673) (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, small bowel resection, or active peptic ulcer disease); patients must not have active small or large intestine inflammation such as Crohn's disease or ulcerative colitis (within 12 months of sub-study registration) - Patients must be able to take oral medications; patients must be able to swallow capsules whole without crushing or altering them in any way - Patients must not be taking, nor plan to take while on protocol treatment strong P-glycoprotein (P-gp) inhibitors, P-gp inducers, or breast cancer resistance protein (BCRP) inhibitors; the language ?P-gp or BCRP inhibitors or inducers? is reworded to ?strong P-gp inhibitors, P-gp inducers, or BCRP inhibitors? for consistency with the investigator brochure - Patients must agree to have blood specimens submitted for pharmacokinetic analysis |
| Country | Name | City | State |
|---|---|---|---|
| Canada | Cross Cancer Institute | Edmonton | Alberta |
| Canada | Juravinski Cancer Centre at Hamilton Health Sciences | Hamilton | Ontario |
| Canada | Ottawa Hospital and Cancer Center-General Campus | Ottawa | Ontario |
| Canada | Allan Blair Cancer Centre | Regina | Saskatchewan |
| Canada | Saskatoon Cancer Centre | Saskatoon | Saskatchewan |
| Canada | University Health Network-Princess Margaret Hospital | Toronto | Ontario |
| United States | Hawaii Oncology Inc-Pali Momi | 'Aiea | Hawaii |
| United States | Pali Momi Medical Center | 'Aiea | Hawaii |
| United States | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii |
| United States | Avera Cancer Institute-Aberdeen | Aberdeen | South Dakota |
| United States | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington |
| United States | New York Oncology Hematology PC -Albany Medical Center | Albany | New York |
| United States | Phoebe Putney Memorial Hospital | Albany | Georgia |
| United States | Lovelace Medical Center-Downtown | Albuquerque | New Mexico |
| United States | Lovelace Medical Center-Saint Joseph Square | Albuquerque | New Mexico |
| United States | New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico |
| United States | University of New Mexico Cancer Center | Albuquerque | New Mexico |
| United States | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania |
| United States | The Don and Sybil Harrington Cancer Center | Amarillo | Texas |
| United States | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah |
| United States | Mary Greeley Medical Center | Ames | Iowa |
| United States | McFarland Clinic PC - Ames | Ames | Iowa |
| United States | Community Hospital of Anaconda | Anaconda | Montana |
| United States | Cancer Care Center at Island Hospital | Anacortes | Washington |
| United States | Kaiser Permanente-Anaheim | Anaheim | California |
| United States | Alaska Breast Care and Surgery LLC | Anchorage | Alaska |
| United States | Alaska Oncology and Hematology LLC | Anchorage | Alaska |
| United States | Alaska Women's Cancer Care | Anchorage | Alaska |
| United States | Anchorage Associates in Radiation Medicine | Anchorage | Alaska |
| United States | Anchorage Oncology Centre | Anchorage | Alaska |
| United States | Anchorage Radiation Therapy Center | Anchorage | Alaska |
| United States | Katmai Oncology Group | Anchorage | Alaska |
| United States | Providence Alaska Medical Center | Anchorage | Alaska |
| United States | AnMed Health Cancer Center | Anderson | South Carolina |
| United States | Saint Joseph Mercy Hospital | Ann Arbor | Michigan |
| United States | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan |
| United States | Langlade Hospital and Cancer Center | Antigo | Wisconsin |
| United States | Kaiser Permanente-Deer Valley Medical Center | Antioch | California |
| United States | PCR Oncology | Arroyo Grande | California |
| United States | Randolph Hospital | Asheboro | North Carolina |
| United States | Asheville Hematology-Oncology Associates | Asheville | North Carolina |
| United States | Cancer Care of Western North Carolina | Asheville | North Carolina |
| United States | Mission Hospital Inc-Memorial Campus | Asheville | North Carolina |
| United States | Duluth Clinic Ashland | Ashland | Wisconsin |
| United States | King's Daughter's Medical Center | Ashland | Kentucky |
| United States | University Cancer and Blood Center LLC | Athens | Georgia |
| United States | Emory Saint Joseph's Hospital | Atlanta | Georgia |
| United States | Emory University Hospital Midtown | Atlanta | Georgia |
| United States | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia |
| United States | Northside Hospital | Atlanta | Georgia |
| United States | MultiCare Auburn Medical Center | Auburn | Washington |
| United States | Sutter Auburn Faith Hospital | Auburn | California |
| United States | Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California |
| United States | Augusta University Medical Center | Augusta | Georgia |
| United States | Harold Alfond Center for Cancer Care | Augusta | Maine |
| United States | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado |
| United States | Rush - Copley Medical Center | Aurora | Illinois |
| United States | University of Colorado Hospital | Aurora | Colorado |
| United States | Mount Sinai Comprehensive Cancer Center at Aventura | Aventura | Florida |
| United States | Virginia Mason Bainbridge Island Medical Center | Bainbridge Island | Washington |
| United States | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon |
| United States | AIS Cancer Center at San Joaquin Community Hospital | Bakersfield | California |
| United States | Kaiser Permanente-Baldwin Park | Baldwin Park | California |
| United States | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri |
| United States | Greater Baltimore Medical Center | Baltimore | Maryland |
| United States | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland |
| United States | Kaiser Permanente-Woodlawn Medical Center | Baltimore | Maryland |
| United States | MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland |
| United States | MedStar Union Memorial Hospital | Baltimore | Maryland |
| United States | Saint Agnes Hospital | Baltimore | Maryland |
| United States | Sinai Hospital of Baltimore | Baltimore | Maryland |
| United States | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland |
| United States | Eastern Maine Medical Center | Bangor | Maine |
| United States | Flaget Memorial Hospital | Bardstown | Kentucky |
| United States | Boston Baskin Cancer Center-Bartlett | Bartlett | Tennessee |
| United States | Baton Rouge General Medical Center | Baton Rouge | Louisiana |
| United States | Hematology/Oncology Clinic LLP | Baton Rouge | Louisiana |
| United States | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana |
| United States | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana |
| United States | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana |
| United States | Medical Center of Baton Rouge | Baton Rouge | Louisiana |
| United States | Ochsner Health Center-Summa | Baton Rouge | Louisiana |
| United States | Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana |
| United States | Bronson Battle Creek | Battle Creek | Michigan |
| United States | Cleveland Clinic Cancer Center Beachwood | Beachwood | Ohio |
| United States | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio |
| United States | UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania |
| United States | Indu and Raj Soin Medical Center | Beavercreek | Ohio |
| United States | Upper Chesapeake Medical Center | Bel Air | Maryland |
| United States | Waldo County General Hospital | Belfast | Maine |
| United States | Nebraska Medicine-Bellevue | Bellevue | Nebraska |
| United States | Overlake Hospital Medical Center | Bellevue | Washington |
| United States | Kaiser Permanente-Bellflower | Bellflower | California |
| United States | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington |
| United States | Strecker Cancer Center-Belpre | Belpre | Ohio |
| United States | Sanford Clinic North-Bemidgi | Bemidji | Minnesota |
| United States | Saint Charles Health System | Bend | Oregon |
| United States | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California |
| United States | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont |
| United States | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania |
| United States | University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf | Iowa |
| United States | Beverly Hospital | Beverly | Massachusetts |
| United States | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine |
| United States | Billings Clinic Cancer Center | Billings | Montana |
| United States | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama |
| United States | Sanford Bismarck Medical Center | Bismarck | North Dakota |
| United States | Illinois CancerCare-Bloomington | Bloomington | Illinois |
| United States | Saint Joseph Medical Center | Bloomington | Illinois |
| United States | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho |
| United States | Saint Luke's Mountain States Tumor Institute | Boise | Idaho |
| United States | Central Care Cancer Center - Bolivar | Bolivar | Missouri |
| United States | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri |
| United States | McFarland Clinic PC-Boone | Boone | Iowa |
| United States | Beth Israel Deaconess Medical Center | Boston | Massachusetts |
| United States | Boston Medical Center | Boston | Massachusetts |
| United States | Massachusetts General Hospital Cancer Center | Boston | Massachusetts |
| United States | Boulder Community Hospital | Boulder | Colorado |
| United States | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado |
| United States | Bozeman Deaconess Hospital | Bozeman | Montana |
| United States | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota |
| United States | Cox Cancer Center Branson | Branson | Missouri |
| United States | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington |
| United States | Harrison Medical Center | Bremerton | Washington |
| United States | Lafayette Family Cancer Center-EMMC | Brewer | Maine |
| United States | Ocean Medical Center | Brick | New Jersey |
| United States | United Hospital Center | Bridgeport | West Virginia |
| United States | IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan |
| United States | Saint Joseph Mercy Brighton | Brighton | Michigan |
| United States | Bronx Veterans Administration Medical Center | Bronx | New York |
| United States | Montefiore Medical Center - Moses Campus | Bronx | New York |
| United States | Montefiore Medical Center-Einstein Campus | Bronx | New York |
| United States | Montefiore Medical Center-Weiler Hospital | Bronx | New York |
| United States | New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York |
| United States | State University of New York Downstate Medical Center | Brooklyn | New York |
| United States | Henry Ford Cancer Institute?Downriver | Brownstown | Michigan |
| United States | Saint Joseph Regional Cancer Center | Bryan | Texas |
| United States | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania |
| United States | Roswell Park Cancer Institute | Buffalo | New York |
| United States | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California |
| United States | Highline Medical Center-Main Campus | Burien | Washington |
| United States | Kaiser Permanente-Burke Medical Center | Burke | Virginia |
| United States | Mills-Peninsula Medical Center | Burlingame | California |
| United States | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin |
| United States | Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina |
| United States | Lahey Hospital and Medical Center | Burlington | Massachusetts |
| United States | University of Vermont College of Medicine | Burlington | Vermont |
| United States | University of Vermont Medical Center | Burlington | Vermont |
| United States | Fairview Ridges Hospital | Burnsville | Minnesota |
| United States | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho |
| United States | Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California |
| United States | Aultman Health Foundation | Canton | Ohio |
| United States | IHA Hematology Oncology Consultants-Canton | Canton | Michigan |
| United States | Illinois CancerCare-Canton | Canton | Illinois |
| United States | Mercy Medical Center | Canton | Ohio |
| United States | Saint Joseph Mercy Canton | Canton | Michigan |
| United States | Saint Francis Medical Center | Cape Girardeau | Missouri |
| United States | Southeast Cancer Center | Cape Girardeau | Missouri |
| United States | Memorial Hospital of Carbondale | Carbondale | Illinois |
| United States | IU Health North Hospital | Carmel | Indiana |
| United States | Caro Cancer Center | Caro | Michigan |
| United States | Carson Tahoe Regional Medical Center | Carson City | Nevada |
| United States | SIH Cancer Institute | Carterville | Illinois |
| United States | Illinois CancerCare-Carthage | Carthage | Illinois |
| United States | Eden Hospital Medical Center | Castro Valley | California |
| United States | Sandra L Maxwell Cancer Center | Cedar City | Utah |
| United States | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio |
| United States | Miami Valley Hospital South | Centerville | Ohio |
| United States | Centralia Oncology Clinic | Centralia | Illinois |
| United States | Providence Regional Cancer System-Centralia | Centralia | Washington |
| United States | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania |
| United States | Cancer Center of Kansas - Chanute | Chanute | Kansas |
| United States | Geauga Hospital | Chardon | Ohio |
| United States | Bon Secours Saint Francis Hospital | Charleston | South Carolina |
| United States | Charleston Hematology Oncology Associates PA-Saint Francis | Charleston | South Carolina |
| United States | Charleston Hematology Oncology Associates-Roper | Charleston | South Carolina |
| United States | Lowcountry Hematology Oncology PA-North Charleston | Charleston | South Carolina |
| United States | Lowcountry Hematology Oncology PA-West Ashley | Charleston | South Carolina |
| United States | Roper Hospital | Charleston | South Carolina |
| United States | West Virginia University Charleston Division | Charleston | West Virginia |
| United States | Novant Health Presbyterian Medical Center | Charlotte | North Carolina |
| United States | Oncology Specialists of Charlotte | Charlotte | North Carolina |
| United States | Southern Oncology Specialists-Charlotte | Charlotte | North Carolina |
| United States | University of Virginia Cancer Center | Charlottesville | Virginia |
| United States | Memorial Hospital | Chattanooga | Tennessee |
| United States | IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan |
| United States | Saint Joseph Mercy Chelsea | Chelsea | Michigan |
| United States | Saint Luke's Hospital | Chesterfield | Missouri |
| United States | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming |
| United States | John H Stroger Jr Hospital of Cook County | Chicago | Illinois |
| United States | Mount Sinai Hospital Medical Center | Chicago | Illinois |
| United States | Northwestern University | Chicago | Illinois |
| United States | Rush University Medical Center | Chicago | Illinois |
| United States | Swedish Covenant Hospital | Chicago | Illinois |
| United States | University of Chicago Comprehensive Cancer Center | Chicago | Illinois |
| United States | Adena Regional Medical Center | Chillicothe | Ohio |
| United States | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin |
| United States | Bethesda North Hospital | Cincinnati | Ohio |
| United States | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc - Anderson | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio |
| United States | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio |
| United States | TriHealth Cancer Institute-Westside | Cincinnati | Ohio |
| United States | University of Cincinnati/Barrett Cancer Center | Cincinnati | Ohio |
| United States | Clackamas Radiation Oncology Center | Clackamas | Oregon |
| United States | Providence Oncology and Hematology Care Southeast | Clackamas | Oregon |
| United States | Hematology Oncology Consultants-Clarkston | Clarkston | Michigan |
| United States | Newland Medical Associates-Clarkston | Clarkston | Michigan |
| United States | Case Western Reserve University | Cleveland | Ohio |
| United States | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio |
| United States | Cleveland Clinic Foundation | Cleveland | Ohio |
| United States | MetroHealth Medical Center | Cleveland | Ohio |
| United States | Greenville Health System Cancer Institute-Laurens | Clinton | South Carolina |
| United States | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina |
| United States | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan |
| United States | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa |
| United States | Mercy Cancer Center-West Lakes | Clive | Iowa |
| United States | Haywood Infusion Center | Clyde | North Carolina |
| United States | Billings Clinic-Cody | Cody | Wyoming |
| United States | Kootenai Medical Center | Coeur d'Alene | Idaho |
| United States | Coffeyville Regional Medical Center | Coffeyville | Kansas |
| United States | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado |
| United States | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado |
| United States | UCHealth Memorial Hospital Central | Colorado Springs | Colorado |
| United States | University of Missouri - Ellis Fischel | Columbia | Missouri |
| United States | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi |
| United States | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio |
| United States | Doctors Hospital | Columbus | Ohio |
| United States | Grant Medical Center | Columbus | Ohio |
| United States | John B Amos Cancer Center | Columbus | Georgia |
| United States | Mount Carmel East Hospital | Columbus | Ohio |
| United States | Mount Carmel Health Center West | Columbus | Ohio |
| United States | Ohio State University Comprehensive Cancer Center | Columbus | Ohio |
| United States | Riverside Methodist Hospital | Columbus | Ohio |
| United States | The Mark H Zangmeister Center | Columbus | Ohio |
| United States | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire |
| United States | Cookeville Regional Medical Center | Cookeville | Tennessee |
| United States | Mercy Hospital | Coon Rapids | Minnesota |
| United States | Mary Imogene Bassett Hospital | Cooperstown | New York |
| United States | Bay Area Hospital | Coos Bay | Oregon |
| United States | UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida |
| United States | Baptist Health Corbin | Corbin | Kentucky |
| United States | Commonwealth Cancer Center-Corbin | Corbin | Kentucky |
| United States | City of Hope Corona | Corona | California |
| United States | Alegent Health Mercy Hospital | Council Bluffs | Iowa |
| United States | Mary Bird Cancer Center/Saint Tammany Parish | Covington | Louisiana |
| United States | Northshore Oncology Associates-Covington | Covington | Louisiana |
| United States | Greater Regional Medical Center | Creston | Iowa |
| United States | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky |
| United States | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri |
| United States | Western Maryland Regional Medical Center | Cumberland | Maryland |
| United States | Northside Hospital-Forsyth | Cumming | Georgia |
| United States | Parkland Memorial Hospital | Dallas | Texas |
| United States | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas |
| United States | Carle on Vermilion | Danville | Illinois |
| United States | Geisinger Medical Center | Danville | Pennsylvania |
| United States | Genesis Medical Center - East Campus | Davenport | Iowa |
| United States | Sutter Davis Hospital | Davis | California |
| United States | Dayton Physicians LLC-Samaritan North | Dayton | Ohio |
| United States | Good Samaritan Hospital - Dayton | Dayton | Ohio |
| United States | Miami Valley Hospital | Dayton | Ohio |
| United States | Samaritan North Health Center | Dayton | Ohio |
| United States | Halifax Health Medical Center-Centers for Oncology | Daytona Beach | Florida |
| United States | Beaumont Hospital-Dearborn | Dearborn | Michigan |
| United States | Henry Ford Medical Center-Fairlane | Dearborn | Michigan |
| United States | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois |
| United States | Decatur Memorial Hospital | Decatur | Illinois |
| United States | Dekalb Medical Center | Decatur | Georgia |
| United States | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida |
| United States | Delaware Health Center-Grady Cancer Center | Delaware | Ohio |
| United States | Delaware Radiation Oncology | Delaware | Ohio |
| United States | Grady Memorial Hospital | Delaware | Ohio |
| United States | Colorado Blood Cancer Institute | Denver | Colorado |
| United States | Denver Health Medical Center | Denver | Colorado |
| United States | Kaiser Permanente-Franklin | Denver | Colorado |
| United States | National Jewish Health-Main Campus | Denver | Colorado |
| United States | Porter Adventist Hospital | Denver | Colorado |
| United States | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado |
| United States | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado |
| United States | Rocky Mountain Cancer Centers-Rose | Denver | Colorado |
| United States | Rose Medical Center | Denver | Colorado |
| United States | SCL Health Saint Joseph Hospital | Denver | Colorado |
| United States | The Women's Imaging Center | Denver | Colorado |
| United States | Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut |
| United States | Broadlawns Medical Center | Des Moines | Iowa |
| United States | Iowa Lutheran Hospital | Des Moines | Iowa |
| United States | Iowa Methodist Medical Center | Des Moines | Iowa |
| United States | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa |
| United States | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa |
| United States | Mercy Medical Center - Des Moines | Des Moines | Iowa |
| United States | Henry Ford Hospital | Detroit | Michigan |
| United States | Saint John Hospital and Medical Center | Detroit | Michigan |
| United States | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan |
| United States | Cancer Center of Kansas - Dodge City | Dodge City | Kansas |
| United States | City of Hope Comprehensive Cancer Center | Duarte | California |
| United States | Essentia Health Cancer Center | Duluth | Minnesota |
| United States | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota |
| United States | Miller-Dwan Hospital | Duluth | Minnesota |
| United States | Mercy Medical Center | Durango | Colorado |
| United States | Southwest Oncology PC | Durango | Colorado |
| United States | Duke University Medical Center | Durham | North Carolina |
| United States | Greenville Health System Cancer Institute-Easley | Easley | South Carolina |
| United States | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan |
| United States | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin |
| United States | Marshfield Clinic Cancer Center - Eau Claire | Eau Claire | Wisconsin |
| United States | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin |
| United States | Fairview-Southdale Hospital | Edina | Minnesota |
| United States | Swedish Medical Center-Edmonds | Edmonds | Washington |
| United States | Carle Physician Group-Effingham | Effingham | Illinois |
| United States | Crossroads Cancer Center | Effingham | Illinois |
| United States | Cancer Center of Kansas - El Dorado | El Dorado | Kansas |
| United States | Hardin Memorial Hospital | Elizabethtown | Kentucky |
| United States | AMITA Health Alexian Brothers Medical Center | Elk Grove Village | Illinois |
| United States | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York |
| United States | Mercy Cancer Center-Elyria | Elyria | Ohio |
| United States | Walter Knox Memorial Hospital | Emmett | Idaho |
| United States | Newman Regional Health | Emporia | Kansas |
| United States | Comprehensive Cancer Care and Research Institute of Colorado LLC | Englewood | Colorado |
| United States | Swedish Medical Center | Englewood | Colorado |
| United States | Saint Elizabeth Hospital | Enumclaw | Washington |
| United States | Ephrata Cancer Center | Ephrata | Pennsylvania |
| United States | Ephrata Community Hospital | Ephrata | Pennsylvania |
| United States | Green Bay Oncology - Escanaba | Escanaba | Michigan |
| United States | Illinois CancerCare-Eureka | Eureka | Illinois |
| United States | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois |
| United States | Saint Francis Hospital | Evanston | Illinois |
| United States | Deaconess Clinic Downtown | Evansville | Indiana |
| United States | Providence Regional Cancer Partnership | Everett | Washington |
| United States | Fairbanks Memorial Hospital | Fairbanks | Alaska |
| United States | JCHC McCreery Cancer Center | Fairfield | Iowa |
| United States | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio |
| United States | Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut |
| United States | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota |
| United States | Roger Maris Cancer Center | Fargo | North Dakota |
| United States | Sanford Broadway Medical Center | Fargo | North Dakota |
| United States | Sanford Clinic North-Fargo | Fargo | North Dakota |
| United States | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan |
| United States | Weisberg Cancer Treatment Center | Farmington Hills | Michigan |
| United States | Cape Fear Valley Health System | Fayetteville | North Carolina |
| United States | Saint Francis Hospital | Federal Way | Washington |
| United States | Virginia Mason Federal Way Medical Center | Federal Way | Washington |
| United States | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota |
| United States | Armes Family Cancer Center | Findlay | Ohio |
| United States | Blanchard Valley Hospital | Findlay | Ohio |
| United States | Orion Cancer Care | Findlay | Ohio |
| United States | IU Health Central Indiana Cancer Centers-Fishers | Fishers | Indiana |
| United States | Simonds-Sinon Regional Cancer Center | Fitchburg | Massachusetts |
| United States | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan |
| United States | Genesee Hematology Oncology PC | Flint | Michigan |
| United States | Genesys Hurley Cancer Institute | Flint | Michigan |
| United States | Hurley Medical Center | Flint | Michigan |
| United States | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin |
| United States | Kaiser Permanente-Fontana | Fontana | California |
| United States | Poudre Valley Hospital | Fort Collins | Colorado |
| United States | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa |
| United States | Holy Cross Hospital | Fort Lauderdale | Florida |
| United States | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas |
| United States | Parkview Hospital Randallia | Fort Wayne | Indiana |
| United States | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio |
| United States | Dayton Physicians LLC-Atrium | Franklin | Ohio |
| United States | Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee |
| United States | Frederick Memorial Hospital | Frederick | Maryland |
| United States | Hematology Oncology Associates of Fredericksburg Inc | Fredericksburg | Virginia |
| United States | Kaiser Permanente-Fremont | Fremont | California |
| United States | Palo Alto Medical Foundation-Fremont | Fremont | California |
| United States | Kaiser Permanente-Fresno | Fresno | California |
| United States | Unity Hospital | Fridley | Minnesota |
| United States | Saint Luke's Mountain States Tumor Institute - Fruitland | Fruitland | Idaho |
| United States | Saint Jude Medical Center | Fullerton | California |
| United States | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina |
| United States | Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia |
| United States | University of Florida Health Science Center - Gainesville | Gainesville | Florida |
| United States | Kaiser Permanente-Gaithersburg Medical Center | Gaithersburg | Maryland |
| United States | Illinois CancerCare-Galesburg | Galesburg | Illinois |
| United States | Western Illinois Cancer Treatment Center | Galesburg | Illinois |
| United States | Central Care Cancer Center - Garden City | Garden City | Kansas |
| United States | Saint Catherine Hospital | Garden City | Kansas |
| United States | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois |
| United States | Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina |
| United States | Aurora Health Care Germantown Health Center | Germantown | Wisconsin |
| United States | Adams Cancer Center | Gettysburg | Pennsylvania |
| United States | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington |
| United States | Tacoma/Valley Radiation Oncology Centers-Gig Harbor | Gig Harbor | Washington |
| United States | Glens Falls Hospital | Glens Falls | New York |
| United States | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois |
| United States | Addison Gilbert Hospital | Gloucester | Massachusetts |
| United States | Mountain Blue Cancer Care Center | Golden | Colorado |
| United States | National Jewish Health-Western Hematology Oncology | Golden | Colorado |
| United States | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina |
| United States | Wayne Memorial Hospital | Goldsboro | North Carolina |
| United States | Aurora Cancer Care-Grafton | Grafton | Wisconsin |
| United States | CHI Health Saint Francis | Grand Island | Nebraska |
| United States | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado |
| United States | Mercy Health Saint Mary's | Grand Rapids | Michigan |
| United States | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan |
| United States | Central Care Cancer Center - Great Bend | Great Bend | Kansas |
| United States | Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas |
| United States | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana |
| United States | Great Falls Clinic | Great Falls | Montana |
| United States | North Colorado Medical Center | Greeley | Colorado |
| United States | Aurora BayCare Medical Center | Green Bay | Wisconsin |
| United States | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin |
| United States | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin |
| United States | Cone Health Cancer Center | Greensboro | North Carolina |
| United States | UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania |
| United States | Dayton Physicians LLC-Wayne | Greenville | Ohio |
| United States | Greenville Health System Cancer Institute-Butternut | Greenville | South Carolina |
| United States | Greenville Health System Cancer Institute-Eastside | Greenville | South Carolina |
| United States | Greenville Health System Cancer Institute-Faris | Greenville | South Carolina |
| United States | Greenville Memorial Hospital | Greenville | South Carolina |
| United States | Saint Francis Cancer Center | Greenville | South Carolina |
| United States | Saint Francis Hospital | Greenville | South Carolina |
| United States | Wayne Hospital | Greenville | Ohio |
| United States | Rocky Mountain Cancer Centers-Greenwood Village | Greenwood Village | Colorado |
| United States | Gibbs Cancer Center-Pelham | Greer | South Carolina |
| United States | Greenville Health System Cancer Institute-Greer | Greer | South Carolina |
| United States | Baptist Cancer Center-Grenada | Grenada | Mississippi |
| United States | Legacy Mount Hood Medical Center | Gresham | Oregon |
| United States | William Beaumont Hospital-Grosse Point | Grosse Pointe | Michigan |
| United States | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan |
| United States | Lymphoma Clinic of Michigan | Grosse Pointe Woods | Michigan |
| United States | Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan |
| United States | Yale-New Haven Shoreline Medical Center | Guilford | Connecticut |
| United States | Cherry Tree Cancer Center | Hanover | Pennsylvania |
| United States | Kaiser Permanente - Harbor City | Harbor City | California |
| United States | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania |
| United States | Hartford Hospital | Hartford | Connecticut |
| United States | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut |
| United States | Ingalls Memorial Hospital | Harvey | Illinois |
| United States | Hays Medical Center | Hays | Kansas |
| United States | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania |
| United States | Saint Peter's Community Hospital | Helena | Montana |
| United States | 21st Century Oncology-Henderson | Henderson | Nevada |
| United States | Cancer and Blood Specialists-Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada |
| United States | Las Vegas Cancer Center-Henderson | Henderson | Nevada |
| United States | Nevada Cancer Specialists-Saint Rose | Henderson | Nevada |
| United States | Hendersonville Hematology and Oncology at Pardee | Hendersonville | North Carolina |
| United States | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina |
| United States | Park Ridge Health | Hendersonville | North Carolina |
| United States | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania |
| United States | Essentia Health Hibbing Clinic | Hibbing | Minnesota |
| United States | High Point Regional Hospital | High Point | North Carolina |
| United States | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois |
| United States | Hines Veterans Administration Hospital | Hines | Illinois |
| United States | AMITA Health Cancer Institute and Outpatient Center | Hinsdale | Illinois |
| United States | Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee |
| United States | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida |
| United States | UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood | Florida |
| United States | Bayshore Community Hospital | Holmdel | New Jersey |
| United States | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii |
| United States | Hawaii Cancer Care Inc-POB II | Honolulu | Hawaii |
| United States | Hawaii Oncology Inc-Kuakini | Honolulu | Hawaii |
| United States | Hawaii Oncology Inc-POB I | Honolulu | Hawaii |
| United States | Island Urology | Honolulu | Hawaii |
| United States | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii |
| United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
| United States | Kuakini Medical Center | Honolulu | Hawaii |
| United States | Queen's Medical Center | Honolulu | Hawaii |
| United States | Straub Clinic and Hospital | Honolulu | Hawaii |
| United States | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii |
| United States | University of Hawaii Cancer Center | Honolulu | Hawaii |
| United States | New Hampshire Oncology Hematology PA-Hooksett | Hooksett | New Hampshire |
| United States | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas |
| United States | Mary Bird Perkins Cancer Center/Terrebonne General Medical Center | Houma | Louisiana |
| United States | Oncology Center of The South Incorporated | Houma | Louisiana |
| United States | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas |
| United States | Ben Taub General Hospital | Houston | Texas |
| United States | M D Anderson Cancer Center | Houston | Texas |
| United States | Michael E DeBakey VA Medical Center | Houston | Texas |
| United States | The Methodist Hospital System | Houston | Texas |
| United States | Lake Norman Hematology Oncology Specialists-Huntersville | Huntersville | North Carolina |
| United States | Southern Oncology Specialists-Huntersville | Huntersville | North Carolina |
| United States | Edwards Comprehensive Cancer Center | Huntington | West Virginia |
| United States | Saint Mary's Medical Center | Huntington | West Virginia |
| United States | Cancer Center of Kansas-Independence | Independence | Kansas |
| United States | Centerpoint Medical Center LLC | Independence | Missouri |
| United States | Cleveland Clinic Cancer Center Independence | Independence | Ohio |
| United States | Franciscan Health Indianapolis | Indianapolis | Indiana |
| United States | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana |
| United States | IU Health Central Indiana Cancer Centers-East | Indianapolis | Indiana |
| United States | IU Health Methodist Hospital | Indianapolis | Indiana |
| United States | Richard L. Roudebush Veterans Affairs Medical Center | Indianapolis | Indiana |
| United States | Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana |
| United States | Springmill Medical Center | Indianapolis | Indiana |
| United States | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa |
| United States | Kaiser Permanente-Irvine | Irvine | California |
| United States | Swedish Cancer Institute-Issaquah | Issaquah | Washington |
| United States | Allegiance Health | Jackson | Michigan |
| United States | University of Mississippi Medical Center | Jackson | Mississippi |
| United States | Onslow Memorial Hospital | Jacksonville | North Carolina |
| United States | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina |
| United States | Mercy Health System | Janesville | Wisconsin |
| United States | McFarland Clinic PC-Jefferson | Jefferson | Iowa |
| United States | Capital Region Southwest Campus | Jefferson City | Missouri |
| United States | Jefferson Hospital | Jefferson Hills | Pennsylvania |
| United States | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin |
| United States | UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania |
| United States | Joliet Oncology-Hematology Associates Limited | Joliet | Illinois |
| United States | Fowler Family Center for Cancer Care | Jonesboro | Arkansas |
| United States | Freeman Health System | Joplin | Missouri |
| United States | Mercy Hospital Joplin | Joplin | Missouri |
| United States | Borgess Medical Center | Kalamazoo | Michigan |
| United States | West Michigan Cancer Center | Kalamazoo | Michigan |
| United States | Kalispell Regional Medical Center | Kalispell | Montana |
| United States | Presence Saint Mary's Hospital | Kankakee | Illinois |
| United States | Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri |
| United States | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri |
| United States | Research Medical Center | Kansas City | Missouri |
| United States | Saint Luke's Hospital of Kansas City | Kansas City | Missouri |
| United States | The University of Kansas Cancer Center-North | Kansas City | Missouri |
| United States | The University of Kansas Cancer Center-South | Kansas City | Missouri |
| United States | Truman Medical Center | Kansas City | Missouri |
| United States | University of Kansas Cancer Center | Kansas City | Kansas |
| United States | University of Kansas Cancer Center-West | Kansas City | Kansas |
| United States | CHI Health Good Samaritan | Kearney | Nebraska |
| United States | Heartland Hematology and Oncology | Kearney | Nebraska |
| United States | Ochsner Medical Center Kenner | Kenner | Louisiana |
| United States | Kadlec Clinic Hematology and Oncology | Kennewick | Washington |
| United States | Northwest Cancer Clinic | Kennewick | Washington |
| United States | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin |
| United States | Kaiser Permanente - Kensington Medical Center | Kensington | Maryland |
| United States | First Dayton Cancer Care | Kettering | Ohio |
| United States | Greater Dayton Cancer Center | Kettering | Ohio |
| United States | Kettering Medical Center | Kettering | Ohio |
| United States | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois |
| United States | Cancer Center of Kansas-Kingman | Kingman | Kansas |
| United States | Vidant Oncology-Kinston | Kinston | North Carolina |
| United States | Seattle Cancer Care Alliance at EvergreenHealth | Kirkland | Washington |
| United States | Armstrong Center for Medicine and Health | Kittanning | Pennsylvania |
| United States | Thompson Cancer Survival Center | Knoxville | Tennessee |
| United States | Thompson Cancer Survival Center - West | Knoxville | Tennessee |
| United States | Gundersen Lutheran Medical Center | La Crosse | Wisconsin |
| United States | UC San Diego Moores Cancer Center | La Jolla | California |
| United States | Providence Regional Cancer System-Lacey | Lacey | Washington |
| United States | Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin |
| United States | Good Samaritan Medical Center | Lafayette | Colorado |
| United States | Kaiser Permanente-Rock Creek | Lafayette | Colorado |
| United States | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado |
| United States | Saint Anthony Hospital | Lakewood | Colorado |
| United States | Saint Clare Hospital | Lakewood | Washington |
| United States | City of Hope Antelope Valley | Lancaster | California |
| United States | Fairfield Medical Center | Lancaster | Ohio |
| United States | Sparrow Hospital | Lansing | Michigan |
| United States | Kaiser Permanente - Largo Medical Center | Largo | Maryland |
| United States | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico |
| United States | 21st Century Oncology | Las Vegas | Nevada |
| United States | 21st Century Oncology-Fort Apache | Las Vegas | Nevada |
| United States | 21st Century Oncology-Vegas Tenaya | Las Vegas | Nevada |
| United States | Ann M Wierman MD LTD | Las Vegas | Nevada |
| United States | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada |
| United States | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada |
| United States | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada |
| United States | Desert West Surgery | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada |
| United States | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada |
| United States | Nevada Cancer Specialists-Fort Apache | Las Vegas | Nevada |
| United States | Nevada Cancer Specialists-Tenaya | Las Vegas | Nevada |
| United States | Nevada Cancer Specialists?Oakey | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada |
| United States | Summerlin Hospital Medical Center | Las Vegas | Nevada |
| United States | University Cancer Center | Las Vegas | Nevada |
| United States | University Medical Center of Southern Nevada | Las Vegas | Nevada |
| United States | Lawrence Memorial Hospital | Lawrence | Kansas |
| United States | Gwinnett Medical Center | Lawrenceville | Georgia |
| United States | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma |
| United States | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire |
| United States | Sechler Family Cancer Center | Lebanon | Pennsylvania |
| United States | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri |
| United States | The University of Kansas Cancer Center-Lee's Summit | Lee's Summit | Missouri |
| United States | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas |
| United States | Minimally Invasive Surgery Hospital | Lenexa | Kansas |
| United States | Beebe Medical Center | Lewes | Delaware |
| United States | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania |
| United States | Lewistown Hospital | Lewistown | Pennsylvania |
| United States | Baptist Health Lexington | Lexington | Kentucky |
| United States | Saint Joseph Hospital East | Lexington | Kentucky |
| United States | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky |
| United States | University of Kentucky/Markey Cancer Center | Lexington | Kentucky |
| United States | Cancer Center of Kansas-Liberal | Liberal | Kansas |
| United States | Liberty Radiation Oncology Center | Liberty | Missouri |
| United States | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii |
| United States | Nebraska Cancer Research Center | Lincoln | Nebraska |
| United States | Nebraska Hematology and Oncology | Lincoln | Nebraska |
| United States | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska |
| United States | Southeast Nebraska Cancer Center | Lincoln | Nebraska |
| United States | Littleton Adventist Hospital | Littleton | Colorado |
| United States | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado |
| United States | Hope Cancer Clinic | Livonia | Michigan |
| United States | Saint Mary Mercy Hospital | Livonia | Michigan |
| United States | Logan Regional Hospital | Logan | Utah |
| United States | Loma Linda University Medical Center | Loma Linda | California |
| United States | Saint Joseph London | London | Kentucky |
| United States | Kaiser Permanente-Lone Tree | Lone Tree | Colorado |
| United States | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado |
| United States | Longmont United Hospital | Longmont | Colorado |
| United States | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado |
| United States | PeaceHealth Saint John Medical Center | Longview | Washington |
| United States | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California |
| United States | Kaiser Permanente-Cadillac | Los Angeles | California |
| United States | Baptist Health Louisville | Louisville | Kentucky |
| United States | Jewish Hospital | Louisville | Kentucky |
| United States | Jewish Hospital Medical Center Northeast | Louisville | Kentucky |
| United States | Norton Audubon Hospital and Medical Campus | Louisville | Kentucky |
| United States | Norton Brownsboro Hospital and Medical Campus | Louisville | Kentucky |
| United States | Norton Hospital Pavilion and Medical Campus | Louisville | Kentucky |
| United States | Norton Suburban Hospital and Medical Campus | Louisville | Kentucky |
| United States | Saints Mary and Elizabeth Hospital | Louisville | Kentucky |
| United States | McKee Medical Center | Loveland | Colorado |
| United States | Lowell General Hospital | Lowell | Massachusetts |
| United States | Covenant Medical Center-Lakeside | Lubbock | Texas |
| United States | Texas Tech University Health Sciences Center-Lubbock | Lubbock | Texas |
| United States | University Medical Center | Lubbock | Texas |
| United States | Lynchburg Hematology-Oncology Clinic | Lynchburg | Virginia |
| United States | Virginia Mason Lynnwood Medical Center | Lynnwood | Washington |
| United States | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan |
| United States | Illinois CancerCare-Macomb | Macomb | Illinois |
| United States | Michigan Breast Specialists-Macomb Township | Macomb | Michigan |
| United States | Central Georgia Gynecologic Oncology | Macon | Georgia |
| United States | Medical Center of Central Georgia | Macon | Georgia |
| United States | University of Wisconsin Hospital and Clinics | Madison | Wisconsin |
| United States | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky |
| United States | Southern Ocean County Medical Center | Manahawkin | New Jersey |
| United States | Norris Cotton Cancer Center-Manchester | Manchester | New Hampshire |
| United States | Cancer Center of Kansas-Manhattan | Manhattan | Kansas |
| United States | Holy Family Memorial Hospital | Manitowoc | Wisconsin |
| United States | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio |
| United States | OhioHealth Mansfield Hospital | Mansfield | Ohio |
| United States | Fairview Maple Grove Medical Center | Maple Grove | Minnesota |
| United States | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota |
| United States | Saint John's Hospital - Healtheast | Maplewood | Minnesota |
| United States | Marietta Memorial Hospital | Marietta | Ohio |
| United States | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin |
| United States | Vince Lombardi Cancer Clinic-Marinette | Marinette | Wisconsin |
| United States | OhioHealth Marion General Hospital | Marion | Ohio |
| United States | Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan |
| United States | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa |
| United States | Marshfield Clinic | Marshfield | Wisconsin |
| United States | Marshfield Medical Center | Marshfield | Wisconsin |
| United States | WVUH-Berkely Medical Center | Martinsburg | West Virginia |
| United States | Sovah Health Martinsville | Martinsville | Virginia |
| United States | Fremont - Rideout Cancer Center | Marysville | California |
| United States | Matthews Radiation Oncology Center | Matthews | North Carolina |
| United States | Novant Health Cancer Specialists-Matthews | Matthews | North Carolina |
| United States | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois |
| United States | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio |
| United States | Ireland Cancer Center Landerbrook Health Center | Mayfield Heights | Ohio |
| United States | Loyola University Medical Center | Maywood | Illinois |
| United States | UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania |
| United States | Kaiser Permanente Tysons Corner Medical Center | McLean | Virginia |
| United States | Cancer Center of Kansas - McPherson | McPherson | Kansas |
| United States | Cone Heath Cancer Center at Mebane | Mebane | North Carolina |
| United States | Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia |
| United States | Riddle Memorial Hospital | Media | Pennsylvania |
| United States | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee |
| United States | Baptist Memorial Hospital for Women | Memphis | Tennessee |
| United States | Family Cancer Center-Memphis | Memphis | Tennessee |
| United States | Community Memorial Hospital | Menomonee Falls | Wisconsin |
| United States | Lake University Ireland Cancer Center | Mentor | Ohio |
| United States | Midstate Medical Center | Meriden | Connecticut |
| United States | Idaho Urologic Institute-Meridian | Meridian | Idaho |
| United States | Saint Luke's Mountain States Tumor Institute - Meridian | Meridian | Idaho |
| United States | East Jefferson General Hospital | Metairie | Louisiana |
| United States | Robert Veith MD LLC | Metairie | Louisiana |
| United States | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida |
| United States | Mount Sinai Medical Center | Miami Beach | Florida |
| United States | Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana |
| United States | Woodland Cancer Care Center | Michigan City | Indiana |
| United States | Southwest General Health Center Ireland Cancer Center | Middleburg Heights | Ohio |
| United States | Dayton Physicians LLC-Signal Point | Middletown | Ohio |
| United States | Mid-Michigan Medical Center - Midland | Midland | Michigan |
| United States | Bon Secours Saint Francis Medical Center | Midlothian | Virginia |
| United States | Dana-Farber/Brigham and Women's Cancer Center at Milford Regional | Milford | Massachusetts |
| United States | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin |
| United States | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin |
| United States | Aurora Sinai Medical Center | Milwaukee | Wisconsin |
| United States | Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin |
| United States | Abbott-Northwestern Hospital | Minneapolis | Minnesota |
| United States | Health Partners Inc | Minneapolis | Minnesota |
| United States | Hennepin County Medical Center | Minneapolis | Minnesota |
| United States | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin |
| United States | Trinity Cancer Care Center | Minot | North Dakota |
| United States | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana |
| United States | City of Hope Mission Hills | Mission Hills | California |
| United States | Community Medical Hospital | Missoula | Montana |
| United States | Kaiser Permanente-Modesto | Modesto | California |
| United States | Memorial Medical Center | Modesto | California |
| United States | Trinity Medical Center | Moline | Illinois |
| United States | Monroe Cancer Center | Monroe | Michigan |
| United States | Forbes Hospital | Monroeville | Pennsylvania |
| United States | UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon | Pennsylvania |
| United States | Franciscan Health Mooresville | Mooresville | Indiana |
| United States | Lake Norman Hematology Oncology Specialists-Mooresville | Mooresville | North Carolina |
| United States | West Virginia University Healthcare | Morgantown | West Virginia |
| United States | Lowcountry Hematology Oncology PA-Mount Pleasant | Mount Pleasant | South Carolina |
| United States | Good Samaritan Regional Health Center | Mount Vernon | Illinois |
| United States | Knox Community Hospital | Mount Vernon | Ohio |
| United States | Skagit Valley Hospital | Mount Vernon | Washington |
| United States | Skagit Valley Hospital Regional Cancer Care Center | Mount Vernon | Washington |
| United States | Palo Alto Medical Foundation-Camino Division | Mountain View | California |
| United States | Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View | California |
| United States | ProHealth D N Greenwald Center | Mukwonago | Wisconsin |
| United States | The Community Hospital | Munster | Indiana |
| United States | Intermountain Medical Center | Murray | Utah |
| United States | Mercy Health Mercy Campus | Muskegon | Michigan |
| United States | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho |
| United States | Saint Luke's Mountain States Tumor Institute - Nampa | Nampa | Idaho |
| United States | AMG Oncology - Naperville | Naperville | Illinois |
| United States | Meharry Medical College | Nashville | Tennessee |
| United States | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee |
| United States | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee |
| United States | Allegheny Valley Hospital | Natrona Heights | Pennsylvania |
| United States | Jersey Shore Medical Center | Neptune | New Jersey |
| United States | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi |
| United States | The Hospital of Central Connecticut | New Britain | Connecticut |
| United States | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut |
| United States | Yale University | New Haven | Connecticut |
| United States | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois |
| United States | Louisiana State University Health Science Center | New Orleans | Louisiana |
| United States | LSU Healthcare Network/Saint Charles | New Orleans | Louisiana |
| United States | Ochsner Medical Center Jefferson | New Orleans | Louisiana |
| United States | Tulane University Health Sciences Center | New Orleans | Louisiana |
| United States | University Medical Center New Orleans | New Orleans | Louisiana |
| United States | Cancer Center of Western Wisconsin | New Richmond | Wisconsin |
| United States | New Ulm Medical Center | New Ulm | Minnesota |
| United States | Columbia University/Herbert Irving Cancer Center | New York | New York |
| United States | Christiana Care Health System-Christiana Hospital | Newark | Delaware |
| United States | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware |
| United States | Helen F Graham Cancer Center | Newark | Delaware |
| United States | Licking Memorial Hospital | Newark | Ohio |
| United States | Medical Oncology Hematology Consultants PA | Newark | Delaware |
| United States | Newark Beth Israel Medical Center | Newark | New Jersey |
| United States | Newark Radiation Oncology | Newark | Ohio |
| United States | Regional Hematology and Oncology PA | Newark | Delaware |
| United States | Providence Newberg Medical Center | Newberg | Oregon |
| United States | Chancellor Center for Oncology | Newburgh | Indiana |
| United States | Cancer Center of Kansas - Newton | Newton | Kansas |
| United States | Lakeland Hospital Niles | Niles | Michigan |
| United States | Faith Regional Health Services Carson Cancer Center | Norfolk | Nebraska |
| United States | Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut |
| United States | Great Plains Health Callahan Cancer Center | North Platte | Nebraska |
| United States | Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut |
| United States | Sutter Cancer Research Consortium | Novato | California |
| United States | Assarian Cancer Center | Novi | Michigan |
| United States | Henry Ford Medical Center-Columbus | Novi | Michigan |
| United States | Thompson Oncology Group-Oak Ridge | Oak Ridge | Tennessee |
| United States | Kaiser Permanente-Oakland | Oakland | California |
| United States | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin |
| United States | Green Bay Oncology - Oconto Falls | Oconto Falls | Wisconsin |
| United States | McKay-Dee Hospital Center | Ogden | Utah |
| United States | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma |
| United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
| United States | Olathe Medical Center | Olathe | Kansas |
| United States | MedStar Montgomery Medical Center | Olney | Maryland |
| United States | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska |
| United States | Alegent Health Immanuel Medical Center | Omaha | Nebraska |
| United States | Alegent Health Lakeside Hospital | Omaha | Nebraska |
| United States | Creighton University Medical Center | Omaha | Nebraska |
| United States | Hematology and Oncology Consultants PC | Omaha | Nebraska |
| United States | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska |
| United States | Nebraska Medicine-Village Pointe | Omaha | Nebraska |
| United States | Nebraska Methodist Hospital | Omaha | Nebraska |
| United States | Oncology Hematology West PC | Omaha | Nebraska |
| United States | University of Nebraska Medical Center | Omaha | Nebraska |
| United States | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon |
| United States | Memorial GYN Plus | Ooltewah | Tennessee |
| United States | Saint Joseph Hospital - Orange | Orange | California |
| United States | Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut |
| United States | Providence Willamette Falls Medical Center | Oregon City | Oregon |
| United States | University of Chicago Medicine-Orland Park | Orland Park | Illinois |
| United States | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin |
| United States | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois |
| United States | Ottumwa Regional Health Center | Ottumwa | Iowa |
| United States | Menorah Medical Center | Overland Park | Kansas |
| United States | Saint Luke's South Hospital | Overland Park | Kansas |
| United States | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas |
| United States | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi |
| United States | Baptist Health Paducah | Paducah | Kentucky |
| United States | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada |
| United States | Palo Alto Medical Foundation Health Care | Palo Alto | California |
| United States | Stanford Cancer Institute Palo Alto | Palo Alto | California |
| United States | Kaiser Permanente - Panorama City | Panorama City | California |
| United States | Paoli Memorial Hospital | Paoli | Pennsylvania |
| United States | Midlands Community Hospital | Papillion | Nebraska |
| United States | Feather River Cancer Center | Paradise | California |
| United States | The Valley Hospital-Luckow Pavilion | Paramus | New Jersey |
| United States | Parker Adventist Hospital | Parker | Colorado |
| United States | Rocky Mountain Cancer Centers-Parker | Parker | Colorado |
| United States | Camden Clark Medical Center | Parkersburg | West Virginia |
| United States | Cancer Center of Kansas - Parsons | Parsons | Kansas |
| United States | Singing River Hospital | Pascagoula | Mississippi |
| United States | Illinois CancerCare-Pekin | Pekin | Illinois |
| United States | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois |
| United States | Memorial Hospital West | Pembroke Pines | Florida |
| United States | Sacred Heart Hospital | Pensacola | Florida |
| United States | Illinois CancerCare-Peoria | Peoria | Illinois |
| United States | Methodist Medical Center of Illinois | Peoria | Illinois |
| United States | OSF Saint Francis Medical Center | Peoria | Illinois |
| United States | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois |
| United States | Illinois CancerCare-Peru | Peru | Illinois |
| United States | Valley Radiation Oncology | Peru | Illinois |
| United States | Fox Chase Cancer Center | Philadelphia | Pennsylvania |
| United States | Temple University Hospital | Philadelphia | Pennsylvania |
| United States | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania |
| United States | FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina |
| United States | Via Christi Hospital-Pittsburg | Pittsburg | Kansas |
| United States | Allegheny General Hospital | Pittsburgh | Pennsylvania |
| United States | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania |
| United States | UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania |
| United States | UPMC-Passavant Hospital | Pittsburgh | Pennsylvania |
| United States | UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania |
| United States | UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania |
| United States | UPMC-Saint Margaret | Pittsburgh | Pennsylvania |
| United States | UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania |
| United States | West Penn Hospital | Pittsburgh | Pennsylvania |
| United States | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida |
| United States | 21st Century Oncology-Pontiac | Pontiac | Michigan |
| United States | Hope Cancer Center | Pontiac | Michigan |
| United States | Newland Medical Associates-Pontiac | Pontiac | Michigan |
| United States | Saint Joseph Mercy Oakland | Pontiac | Michigan |
| United States | Huron Medical Center PC | Port Huron | Michigan |
| United States | Lake Huron Medical Center | Port Huron | Michigan |
| United States | Jefferson Healthcare | Port Townsend | Washington |
| United States | Kaiser Permanente Northwest | Portland | Oregon |
| United States | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon |
| United States | Mercy Hospital | Portland | Maine |
| United States | Oregon Health and Science University | Portland | Oregon |
| United States | Providence Portland Medical Center | Portland | Oregon |
| United States | Providence Saint Vincent Medical Center | Portland | Oregon |
| United States | SWOG | Portland | Oregon |
| United States | Southern Ohio Medical Center | Portsmouth | Ohio |
| United States | Kootenai Cancer Center | Post Falls | Idaho |
| United States | Pottstown Hospital | Pottstown | Pennsylvania |
| United States | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania |
| United States | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington |
| United States | Peninsula Cancer Center | Poulsbo | Washington |
| United States | Cancer Center of Kansas - Pratt | Pratt | Kansas |
| United States | Illinois CancerCare-Princeton | Princeton | Illinois |
| United States | Utah Valley Regional Medical Center | Provo | Utah |
| United States | Rocky Mountain Cancer Centers - Pueblo | Pueblo | Colorado |
| United States | Saint Mary Corwin Medical Center | Pueblo | Colorado |
| United States | MultiCare Good Samaritan Hospital | Puyallup | Washington |
| United States | Tacoma/Valley Radiation Oncology Centers-Puyallup | Puyallup | Washington |
| United States | Aurora Cancer Care-Racine | Racine | Wisconsin |
| United States | Duke Raleigh Hospital | Raleigh | North Carolina |
| United States | City of Hope Rancho Cucamonga | Rancho Cucamonga | California |
| United States | Eisenhower Medical Center | Rancho Mirage | California |
| United States | Northwest Hospital Center | Randallstown | Maryland |
| United States | Rapid City Regional Hospital | Rapid City | South Dakota |
| United States | Penn State Health Saint Joseph Medical Center | Reading | Pennsylvania |
| United States | Riverview Medical Center/Booker Cancer Center | Red Bank | New Jersey |
| United States | Saint Charles Health System-Redmond | Redmond | Oregon |
| United States | Kaiser Permanente-Redwood City | Redwood City | California |
| United States | Spectrum Health Reed City Hospital | Reed City | Michigan |
| United States | Beebe Health Campus | Rehoboth Beach | Delaware |
| United States | Annie Penn Memorial Hospital | Reidsville | North Carolina |
| United States | Radiation Oncology Associates | Reno | Nevada |
| United States | Renown Regional Medical Center | Reno | Nevada |
| United States | Saint Mary's Regional Medical Center | Reno | Nevada |
| United States | Valley Medical Center | Renton | Washington |
| United States | Lakeview Medical Center-Marshfield Clinic | Rice Lake | Wisconsin |
| United States | Marshfield Clinic-Rice Lake Center | Rice Lake | Wisconsin |
| United States | Bon Secours Saint Mary's Hospital | Richmond | Virginia |
| United States | Kaiser Permanente-Richmond | Richmond | California |
| United States | Reid Health | Richmond | Indiana |
| United States | Virginia Cancer Institute | Richmond | Virginia |
| United States | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia |
| United States | Neurosurgeons of New Jersey-Ridgewood | Ridgewood | New Jersey |
| United States | Valley Hospital | Ridgewood | New Jersey |
| United States | Kaiser Permanente-Riverside | Riverside | California |
| United States | Riverton Hospital | Riverton | Utah |
| United States | North Memorial Medical Health Center | Robbinsdale | Minnesota |
| United States | Mayo Clinic | Rochester | Minnesota |
| United States | University of Rochester | Rochester | New York |
| United States | Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills | Michigan |
| United States | Penobscot Bay Medical Center | Rockport | Maine |
| United States | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri |
| United States | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri |
| United States | Harbin Clinic Medical Oncology and Clinical Research | Rome | Georgia |
| United States | Kaiser Permanente-Roseville | Roseville | California |
| United States | Michigan Cancer Specialists | Roseville | Michigan |
| United States | Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California |
| United States | Sutter Roseville Medical Center | Roseville | California |
| United States | Cancer Care Associates PC | Royal Oak | Michigan |
| United States | Comprehensive Medical Center PLLC | Royal Oak | Michigan |
| United States | Hematology Oncology Consultants PC | Royal Oak | Michigan |
| United States | Oakland Colon and Rectal Association | Royal Oak | Michigan |
| United States | Oakland Medical Group | Royal Oak | Michigan |
| United States | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan |
| United States | Kaiser Permanente - Sacramento | Sacramento | California |
| United States | Kaiser Permanente Downtown Commons | Sacramento | California |
| United States | Kaiser Permanente-South Sacramento | Sacramento | California |
| United States | Sutter Medical Center Sacramento | Sacramento | California |
| United States | University of California Davis Comprehensive Cancer Center | Sacramento | California |
| United States | Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan |
| United States | Saint Mary's of Michigan | Saginaw | Michigan |
| United States | Dixie Medical Center Regional Cancer Center | Saint George | Utah |
| United States | Saint Helena Hospital | Saint Helena | California |
| United States | Heartland Regional Medical Center | Saint Joseph | Missouri |
| United States | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan |
| United States | Marie Yeager Cancer Center | Saint Joseph | Michigan |
| United States | Mercy Hospital Saint Louis | Saint Louis | Missouri |
| United States | Missouri Baptist Medical Center | Saint Louis | Missouri |
| United States | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri |
| United States | Siteman Cancer Center at Christian Hospital | Saint Louis | Missouri |
| United States | Siteman Cancer Center-South County | Saint Louis | Missouri |
| United States | Washington University School of Medicine | Saint Louis | Missouri |
| United States | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota |
| United States | Regions Hospital | Saint Paul | Minnesota |
| United States | United Hospital | Saint Paul | Minnesota |
| United States | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri |
| United States | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri |
| United States | Salem Hospital | Salem | Oregon |
| United States | Cancer Center of Kansas - Salina | Salina | Kansas |
| United States | Salina Regional Health Center | Salina | Kansas |
| United States | Peninsula Regional Medical Center | Salisbury | Maryland |
| United States | LDS Hospital | Salt Lake City | Utah |
| United States | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah |
| United States | University of Texas Health Science Center at San Antonio | San Antonio | Texas |
| United States | Kaiser Permanente-San Diego Mission | San Diego | California |
| United States | Kaiser Permanente-San Diego Zion | San Diego | California |
| United States | California Pacific Medical Center-Pacific Campus | San Francisco | California |
| United States | Kaiser Permanente-San Francisco | San Francisco | California |
| United States | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California |
| United States | Kaiser Permanente San Leandro | San Leandro | California |
| United States | Kaiser Permanente-San Marcos | San Marcos | California |
| United States | Kaiser Permanente-San Rafael | San Rafael | California |
| United States | Kaiser San Rafael-Gallinas | San Rafael | California |
| United States | Kootenai Cancer Clinic | Sandpoint | Idaho |
| United States | Ireland Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio |
| United States | North Coast Cancer Care | Sandusky | Ohio |
| United States | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine |
| United States | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California |
| United States | Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California |
| United States | Kaiser Permanente-Santa Rosa | Santa Rosa | California |
| United States | Sutter Pacific Medical Foundation | Santa Rosa | California |
| United States | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia |
| United States | Low Country Cancer Care Associates PC | Savannah | Georgia |
| United States | Memorial Health University Medical Center | Savannah | Georgia |
| United States | Summit Cancer Care-Candler | Savannah | Georgia |
| United States | Summit Cancer Care-Memorial | Savannah | Georgia |
| United States | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania |
| United States | Regional West Medical Center Cancer Center | Scottsbluff | Nebraska |
| United States | Community Medical Center | Scranton | Pennsylvania |
| United States | Nanticoke Memorial Hospital | Seaford | Delaware |
| United States | Fred Hutchinson Cancer Research Center | Seattle | Washington |
| United States | Kaiser Permanente Washington | Seattle | Washington |
| United States | Pacific Gynecology Specialists | Seattle | Washington |
| United States | Seattle Cancer Care Alliance | Seattle | Washington |
| United States | Seattle Cancer Care Alliance at Northwest Hospital | Seattle | Washington |
| United States | Swedish Medical Center-Ballard Campus | Seattle | Washington |
| United States | Swedish Medical Center-First Hill | Seattle | Washington |
| United States | University of Washington Medical Center | Seattle | Washington |
| United States | Virginia Mason Medical Center | Seattle | Washington |
| United States | PeaceHealth United General Medical Center | Sedro-Woolley | Washington |
| United States | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania |
| United States | Greenville Health System Cancer Institute-Seneca | Seneca | South Carolina |
| United States | UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania |
| United States | Saint Francis Regional Medical Center | Shakopee | Minnesota |
| United States | HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin |
| United States | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin |
| United States | Providence Regional Cancer System-Shelton | Shelton | Washington |
| United States | Jewish Hospital Medical Center South | Shepherdsville | Kentucky |
| United States | Welch Cancer Center | Sheridan | Wyoming |
| United States | Dayton Physicians LLC-Wilson | Sidney | Ohio |
| United States | Siouxland Regional Cancer Center | Sioux City | Iowa |
| United States | Avera Cancer Institute | Sioux Falls | South Dakota |
| United States | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota |
| United States | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota |
| United States | North Shore Medical Center | Skokie | Illinois |
| United States | Robert Wood Johnson University Hospital Somerset | Somerville | New Jersey |
| United States | Memorial Hospital of South Bend | South Bend | Indiana |
| United States | VCU Community Memorial Health Center | South Hill | Virginia |
| United States | City of Hope South Pasadena | South Pasadena | California |
| United States | Kaiser Permanente-South San Francisco | South San Francisco | California |
| United States | Dana-Farber/Brigham and Women's Cancer Center at South Shore | South Weymouth | Massachusetts |
| United States | Providence Hospital-Southfield Cancer Center | Southfield | Michigan |
| United States | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi |
| United States | Greenville Health System Cancer Institute-Spartanburg | Spartanburg | South Carolina |
| United States | Spartanburg Medical Center | Spartanburg | South Carolina |
| United States | Cancer Care Northwest - Spokane South | Spokane | Washington |
| United States | Cancer Care Northwest-North Spokane | Spokane | Washington |
| United States | Cancer Care Northwest-Valley | Spokane | Washington |
| United States | Rockwood Cancer Treatment Center-DHEC-Downtown | Spokane | Washington |
| United States | Rockwood North Cancer Treatment Center | Spokane | Washington |
| * Note: There are 1157 locations in all - only the first 1000 are shown. | |||
| Lead Sponsor | Collaborator |
|---|---|
| Southwest Oncology Group | National Cancer Institute (NCI) |
United States, Canada,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Other | Homologous Recombination Deficiency (HRD) Immunohistochemistry Score | A logistic regression model will be used as both a continuous variable and categorized as high versus low. A Cox regression model will be used to assess associations with progression free survival and overall survival. | Up to 3 years | |
| Other | PARP Protein Expression Levels Assessed by Immunohistochemistry | A logistic regression model will be used to evaluate if HRD score (as both a continuous variable and categorized as high versus low) and PARP protein expression levels are associated with response. Similarly, a Cox regression model will be used to assess associations with progression free survival and overall survival. | Up to 3 years | |
| Primary | Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-positive (MDVN) Participants | The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes). With 40 HRRD subset positive patients, overall response rate can be estimated within 13% with 95% confidence. |
Up to 3 years post sub-study registration | |
| Secondary | Investigator-assessed Progression-free Survival (IA-PFS) in HRRD-positive (MDVN) Participants | From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause. Participants last known to be alive without report of progression were censored at date of last disease assessment. Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes). |
Up to 3 years post sub-study registration | |
| Secondary | Overall Survival (OS) in HRRD-positive (MDVN) Participants | From date of sub-study registration to date of death due to any cause. Participants last known to be alive were censored at date of last contact. Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes). |
Up to 3 years post sub-study registration | |
| Secondary | Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-positive (FMI) Participants | The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed using a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes). |
3 years post sub-study registration | |
| Secondary | Investigator-assessed Progression Free Survival (IA-PFS) FEP in HRRD-positive (FMI) Participants | From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause. Participants last known to be alive without report of progression were censored at date of last disease assessment. Analysis was performed using a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes). |
3 years post sub-study registration | |
| Secondary | Overall Survival (OS) in HRRD-positive (FMI) Participants | From date of sub-study registration to date of death due to any cause. Participants last known to be alive were censored at date of last contact. Analysis was performed using a broad definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes). |
3 years post sub-study registration | |
| Secondary | Duration of Response in HRRD-positive (FMI) Participants | From date of documentation of response (complete or partial) to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause among participants who achieve a complete or partial response. | Up to 3 years | |
| Secondary | Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-negative Per MDVN But HRRD-positive Per FMI Participants | The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed on participants that meet a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc.) but not the stricter definition set by MDVN. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes). |
3 years post sub-study registration | |
| Secondary | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Adverse Events (AEs) are reported by CTCAE Version 4.0. Only adverse events that are possibly, probably or definitely related to study drug are reported. | Duration of treatment and follow up until death or 3 years post registration |
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