Brain Tumor Clinical Trial
— SJCITOfficial title:
Constraint Induced Movement Therapy in a Pediatric Oncology Population (SJCIT): A Pilot Study
Hemiplegia (weakness or poor muscle function on one side of the body) is a neurological
impairment which can occur in children as a result of a brain tumor or related treatment.
This impairment can negatively impact the child's functional abilities and movement
development, making it difficult for them to play, learn to feed, dress or bathe themselves,
and to participate fully in home, daycare, or school environments. Poor movement skills may
also impact overall quality of life. Constraint Induced Therapy is a rehabilitation
technique which has been found to improve the child's abilities to move their arms following
neurological injuries like stroke and traumatic brain injury in both adults and children.
The aim of this study is to evaluate the feasibility of implementing a constraint induced
movement therapy program in a small group of children with a brain tumor and hemiplegia.
Children who participate in the program may experience improved ability to use their weak
arm leading to increased participation in meaningful activity and improved quality of life.
Status | Completed |
Enrollment | 10 |
Est. completion date | December 2013 |
Est. primary completion date | December 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 2 Years to 12 Years |
Eligibility |
Inclusion Criteria: - Diagnosed hemiplegia of an upper extremity as documented by physician or rehabilitation clinician in the medical record - Diagnosis of brain tumor - English speaking - Participant has demonstrated the ability in the past to move the elbow >70 degrees and has some purposeful movement in the hand (ability to initiate a gross grasp). - Parent/legal guardian is willing to give consent to participate in the study. - Child is willing to give assent in the study if seven years old or older. Exclusion Criteria: - Severe hemiplegia and resulting active range of motion deficits at the affected upper extremity as defined by the following: - < 30 degrees active shoulder flexion or abduction - Inability to initiate active elbow flexion or extension. - Inability to initiate movements at the of wrist, finger or thumb - Uncontrolled seizures that interfere with daily activities, as this would interfere with the participant's ability to fully participate in the CI Therapy program. - Pain that significantly interferes with the participant's ability to fully participate in the intensive therapy program. This includes pain related to subluxation of the shoulder, as measured by a pain rating of 5/10 or greater on the FACES or Numeric Pain Scale. - Currently receiving oral or intravenous chemotherapy or radiation therapy. - Inability or unwillingness of legal guardian to give written informed consent. - Child is unwilling to give assent if seven years old or older. |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Country | Name | City | State |
---|---|---|---|
United States | St. Jude Children's Research Hospital | Memphis | Tennessee |
Lead Sponsor | Collaborator |
---|---|
St. Jude Children's Research Hospital |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of participants who complete the study. | To evaluate the feasibility of conducting a 3-week constraint-induced therapy program in patients with upper extremity hemiplegia as a result of a tumor. We will conclude that conducting this constraint induced therapy program is not feasible if more than 2 patients out of eight patients do not complete the program for any reason, with exception those outlined as excused reasons for absence from a therapy sessions (acute illness of the participant, illness of a parent, or other interruptions considered allowable/unavoidable by the study PI). | One (1) year | No |
Secondary | Frequency of extremity use. | To describe the change in amount of extremity use at pre-intervention, post-intervention and at follow-up. | Baseline, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 7 weeks, 4 months | No |
Secondary | Quality of extremity function. | To describe the change in quality of extremity use at pre-intervention, post-intervention and at follow-up. | Baseline, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 7 weeks, 4 months | No |
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