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Clinical Trial Summary

Investigators propose to develop hyperpolarized [13C]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism and synthesis of a neurotransmitter in this observational study.


Clinical Trial Description

Investigators will perform a pilot study to test the translational feasibility by evaluating sensitivity and repeatability of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate in healthy human subjects (n =10 each). Each subject will be imaged twice using the same hyperpolarized substrate with an interval (<45min) between the injections to evaluate repeatability. Finally, eight subjects will be imaged with both hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate for comparison. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03849963
Study type Observational
Source University of Texas Southwestern Medical Center
Contact
Status Enrolling by invitation
Phase
Start date July 30, 2020
Completion date December 31, 2024

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