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Clinical Trial Summary

This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion.

Hypotheses

1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia.

2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow.

3. Altered oxygen consumption during hyperketonemia in healthy subjects.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science


Related Conditions & MeSH terms


NCT number NCT02357550
Study type Interventional
Source University of Aarhus
Contact
Status Completed
Phase N/A
Start date March 2015
Completion date January 2016

See also
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Completed NCT03473678 - Dietary Nitrate and Healthy Older Adults N/A