Brain Injuries Clinical Trial
Official title:
Cognitive and Physical Effects of Exercise or Exercise With Enrichment on People With TBI
The purpose of this study is to determine whether exercise or exercise with enrichment is beneficial in individuals who previously had a head injury. The enrichment will consist of a cultural educational program that will include ethnic food, music, slides and a talk. A series of tests that measure mental function and balance will be done before and after the exercise or the exercise/enrichment program will be done to measure efficacy.
Traumatic brain injury (TBI) results in long-lasting physical and cognitive deficits. The
purpose of this study is to determine whether exercise or exercise with enrichment is
beneficial in individuals who previously had a head injury. The environmental enrichment will
consist of a cultural educational program that will include ethnic food, music, slides and a
talk on 8 different cultures. Individuals will be evaluated using neuropsychological and
physical tests before and after the intervention. Testing will consist of Repeatable Battery
for the Assessment of Neuropsychological Status (RBANS), Trailmaking Test (TMT), Immediate
Post-Concussion Assessment and Cognitive Testing (ImPACT), Quality of Life in Brain Injury
Questionnaire (QOLIBRI), 10 meter walk, and the NIH Toolbox Standing Balance Test. Initial
testing will include the Disability Rating Scale to help balance groups (after random
assignment) in terms of baseline ability.
In rodents, exercise or an enriched environment after TBI improve cognitive function and
motor function and the combination results in even greater improvement. The mechanism of
cognitive improvement from exercise or environmental enrichment relates to increases in brain
derived neurotrophic factor and neurogenesis in the hippocampus. An additional possible
mechanism of the positive effects of exercise or enrichment is a reduction in inflammation.
Our hypothesis is that exercise or exercise with enrichment will result in better motor
performance and improved cognitive ability.
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