Brain Injuries Clinical Trial
Official title:
Computed Tomography Perfusion in Patients With Severe Head Injury
Traumatic brain injury (TBI) is a leading cause of post-injury hospitalization, disability,
and death worldwide. In Nova Scotia, approximately 50% of major trauma reported is head
trauma. TBI is predicted to be the most common and expensive neurological condition in
Canada through the year 2031.
Families and medical teams must often decide on the appropriate level of care for patients
with severe TBI and frequently need to consider withdrawal of life support measures. These
decisions have implications for patients with severe TBI, costs to the health care system,
and rates of organ donation.
A reliable method for neurological evaluation at the time of the patient's arrival to the
hospital is important, because it is possible that many patients with severe TBI already
have permanent brain damage. Assessing this brain damage with clinical tests is difficult
because of the nature of patients' injuries and the sedative medication they receive at the
time of their hospital admission. Current standard imaging technique for these patients is
severely limited in the assessment of the extent and severity of the brain damage.
Advanced diagnostic imaging, called Computed Tomography Perfusion (CTP), can help detect
permanent brain damage. However, CTP of the head is not currently done for patients with
severe TBI when they arrive at the hospital. The investigators want to test whether CTP of
the head can detect permanent brain damage among patients with severe TBI.
Status | Not yet recruiting |
Enrollment | 50 |
Est. completion date | December 2018 |
Est. primary completion date | September 2018 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - at least 18 years old - severe head injury with Glasgow Coma Scale score = 8 after initial resuscitation - on mechanical respiratory support at the time of imaging Exclusion Criteria: - known to be pregnant - any known contraindication to CT contrast agent, such as an allergy or anaphylactic reaction - known end-stage renal disease (on chronic dialysis or to be expected) |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
Canada | Queen Elizabeth II Health Sciences Centre-Halifax Infirmary | Halifax | Nova Scotia |
Lead Sponsor | Collaborator |
---|---|
Nova Scotia Health Authority |
Canada,
Shankar JJ, Vandorpe R. CT perfusion for confirmation of brain death. AJNR Am J Neuroradiol. 2013 Jun-Jul;34(6):1175-9. doi: 10.3174/ajnr.A3376. Epub 2012 Dec 28. — View Citation
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---|---|---|---|---|
Primary | death | the death of the participant due to any cause at discharge | until hospital discharge, up to 1 year | No |
Secondary | recruitment rate | Number of potential participants approached who agreed to participate | through study completion, up to 2 years | No |
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