Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

Status Recruiting

Clinical Trial Summary

The purpose of this study is to:

1. Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury

2. Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury

3. Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00522496
Study type	Observational
Source	University of Calgary
Contact	David A Zygun, MD
Phone	403-944-1691
Email	dzygun@ucalgary.ca
Status	Recruiting
Phase	N/A
Start date	July 2007
Completion date	August 2009

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