Brain Edema Clinical Trial
Official title:
Non-invasive Monitoring and Serum Marker Study in Children With Cerebral Edema
Purpose of the study：This study aimed to evaluate the clinical significance of serum SUR1, TRPM4 and MMP-9 in the diagnosis of cerebral edema in children with cerebral edema admitted to PICU by comparing them with CT results and perturbation coefficients, so as to provide biological indicators for clinical diagnosis of cerebral edema and provide targets for the treatment of cerebral edema in various diseases.
Early and efficient use of various measures to control and monitor peripheral cerebral edema and intracranial pressure, timely and accurate adjustment of treatment plan to reduce the degree of cerebral edema and reduce intracranial pressure, can significantly improve the development of the disease and prognosis recovery. At present, the clinical diagnosis of cerebral edema is mainly through clinical manifestations and imaging examinations, and there is a lack of corresponding biological examination methods.Purpose of the study：1.By analyzing the correlation between serum SUR1, TRPM4, MMP-9 and the electromagnetic disturbance coefficient, cranial CT results, Glasgow coma score, S100-β, NSE and prognostic score at 3 months of discharge, the clinical value of serum SUR1, TRPM4, MMP-9 and perturbation coefficient in the diagnosis, intracranial pressure monitoring, condition assessment and prognosis judgment of cerebral edema in children was explored.2.By analyzing the changes of the above indicators in various children with cerebral edema admitted to PICU, the types of cerebral edema and the cellular and molecular mechanisms of cerebral edema caused by different diseases were explored. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00409058 -
Teen Online Problem Solving (TOPS) - An Online Intervention Following TBI
|
N/A | |
| Completed |
NCT03323580 -
Effects of Intraoperative GDFT on the Postoperative Brain Edema
|
N/A | |
| Completed |
NCT02368366 -
Comparative Effectiveness of Family Problem-Solving Therapy (F-PST) for Adolescent TBI
|
N/A | |
| Not yet recruiting |
NCT04623307 -
Non-contact DCS-Speckle Multi-parameter Imaging for Neurological Diseases
|
||
| Completed |
NCT00088166 -
XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors
|
Phase 3 | |
| Completed |
NCT04311359 -
A Pharmacovigilance Study of Brain Oedema
|
||
| Completed |
NCT03957837 -
Optical Nerve Sheath Changes During Head Down Laparoscopy
|
||
| Completed |
NCT02701582 -
Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
|
N/A | |
| Not yet recruiting |
NCT06307743 -
Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke
|
N/A | |
| Completed |
NCT03573999 -
Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation
|
Phase 4 | |
| Terminated |
NCT01369121 -
Tolerability Study of Xerecept® in Pediatric Patients
|
Phase 1/Phase 2 | |
| Completed |
NCT05070182 -
Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)
|
||
| Completed |
NCT00226655 -
An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies
|
Phase 3 | |
| Recruiting |
NCT02320955 -
Swiss Prospective Autologous Bone Flap Resorption Study
|
||
| Completed |
NCT02037815 -
Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy
|
Phase 4 | |
| Completed |
NCT02594137 -
A Comparison Between Two Techniques for Performing Decompressive Craniectomy
|
N/A | |
| Withdrawn |
NCT00226668 -
XERECEPT® (hCRF) for Primary Glioma Patients Requiring Dexamethasone to Treat Peritumoral Brain Edema
|
Phase 3 | |
| Terminated |
NCT01054404 -
Furosemide vs Placebo for Brain Relaxation
|
N/A | |
| Recruiting |
NCT05622461 -
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
|
N/A | |
| Completed |
NCT06327737 -
Diabetic Ketoacidosis Diagnosis and Management
|