The s100β Levels in Patients With Mild Brain Injury.

Status Not yet recruiting

Clinical Trial Summary

Mild traumatic brain injury (TBI) accounts for the majority of TBI. At present, whether TBI has traumatic intracranial lession is mainly diagnosed by computed tomography (CT), while only 5% of mild TBI has positive CT results. The risk stratification method for patients with mild TBI is needed to reduce unnecessary CT use and reduce medical costs. S100β is a protein in glial cells and can be used as a biomarker of brain injury. S100β is showed to have the clinical and economic value in ruling out traumatic intracranial lesions in mild TBI patients in Europe and the United States. However, it was showed to have difference between races, and there lacks systematic research data from Chinese population. In addition, if it is used for emergency departments, it is necessary to evaluate new rapid detection methods. This study is based on a novel fast S100β test. The reference intervals of S100β in Chinese adults will be established. Further, evaluation of S100β in diagnosis of traumatic intracranial lesions in acute mild TBI will be conducted from the perspective of clinical and economic value in China, which will provide data for screening of low-risk TBI patients and avoiding unnecessary CT use in clinical practice.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06131242
Study type	Observational
Source	Qianfoshan Hospital
Contact	Sumei Lu
Phone	18615218391
Email	lsmqianyi@126.com
Status	Not yet recruiting
Phase
Start date	November 9, 2023
Completion date	August 31, 2026

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02299128` - Effectiveness of Early Physical Therapy Intervention for Patients With Dizziness After a Sports-Related Concussion	N/A
Completed	`NCT02383472` - LED Therapy for the Treatment of Concussive Brain Injury	N/A
Recruiting	`NCT06112093` - Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches	N/A
Terminated	`NCT02597504` - Development of a Neurocognitive Screening Test	N/A
Completed	`NCT00409058` - Teen Online Problem Solving (TOPS) - An Online Intervention Following TBI	N/A
Completed	`NCT00295074` - The Effect of Mild Traumatic Brain Injury on Recovery From Injury	N/A
Completed	`NCT00483444` - Telephone Follow-Up on Outcome After Mild Traumatic Brain Injury	N/A
Completed	`NCT03319966` - Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury
Completed	`NCT04681742` - Feasibility Testing of Cognitive Strategy Training in Post-Concussive Syndrome	N/A
Completed	`NCT03759223` - Enhanced Problem-Solving Training	N/A
Completed	`NCT00857207` - Metacognitive Training to Enhance Strategy Use in Blast-Related TBI	N/A
Completed	`NCT02368366` - Comparative Effectiveness of Family Problem-Solving Therapy (F-PST) for Adolescent TBI	N/A
Completed	`NCT02858544` - Concussion in Motor Vehicle Accidents: The Concussion Identification Index	N/A
Completed	`NCT00142090` - Use of Salt-Water Solution to Improve Symptoms in Concussion	N/A
Recruiting	`NCT05837676` - Problem-Solving Training for Concussion	N/A
Recruiting	`NCT06015451` - Exercise in Postconcussion Symptoms and Posttraumatic Headache	N/A
Completed	`NCT00724607` - Brain Injury Outcomes (BIO) Study
Unknown status	`NCT02699359` - Indirect Intracranial Pressure Measurement in Patients With Suspected or Documented Concussion	N/A
Completed	`NCT02455037` - Evaluation of a Neck Strengthening Program to Reduce the Risk of Sport-related Concussion	N/A
Completed	`NCT02486003` - Testing mTBI in Athletes	N/A