AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults

Brain Aging Clinical Trial

— AvoCog  

Official title:

AvoCog - The Effect of Daily Avocado Intake on Cognitive Function in Older Adults

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06137339
• Other study ID #: 00150975
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 2024
• Est. completion date: December 2025

Study information

• Verified date: November 2023
• Source: University of Kansas Medical Center
• Contact: Emma Kelly, MS
• Phone: 913-588-7683
• Email: ekelly9[@]kumc.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia. We will test for change in functional MRI, cognitive performance, and brain blood flow. Intervention group participants will be asked to consume 1 avocado per day for 12 weeks. Participants in the control group will be asked to continue their normal intake for 12 weeks. Throughout the study, participants will be asked to perform cognitive tests, MRI, blood tests, and questionnaires.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 70
• Est. completion date: December 2025
• Est. primary completion date: December 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 85 Years

Eligibility

Inclusion Criteria:

• Males and females aged 65-85 years
• Good general health with no concomitant disease
• BMI 18.5 - 35 kg/m2
• Mini Mental State Exam =26
• Reports consuming =2 medium avocados per month
• Reports consuming =3 servings of carotenoid-rich foods per week and =3 servings of fruits and vegetables per day
• Skin carotenoid content <400

Exclusion Criteria:

• Unwilling or unable to consume avocado
• Latex allergy
• Consistently taking lutein + zeaxanthin supplements
• Skin carotenoid content =400
• Central neurological disease such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, brain tumor, etc.
• Serious medical risk: cancer requiring chemotherapy or radiation within the past 5 years, recent cardiac event (i.e. heart attack, etc.)
• Diabetes mellitus or uncontrolled hypertension
• Use of psychoactive or investigational medications
• Consumption of =3 alcoholic drinks per day or substance abuse
• Unable to undergo MRI

Related Conditions & MeSH terms

• Brain Aging

Intervention

Other:
• Avocado Group
Participants will consume provided avocados daily and track consumption for the duration of the study. Participants will be adding avocados to their diet and will receive education on maintaining usual diet.

Locations

Country	Name	City	State
United States	University of Kansas Medical Center	Kansas City	Kansas

Sponsors (2)

Lead Sponsor	Collaborator
University of Kansas Medical Center	Avocado Nutrition Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in brain activity	MRI will be used to measure changes in brain activity during resting state, a working memory task, and executive function task.	Baseline and 12 weeks
Secondary	Changes in cerebral blood flow	MRI will be used to measure change in cerebral blood flow.	Baseline and 12 weeks
Secondary	Changes in memory and executive function	NIH Toolbox will be used to measure change in cognition throughout the study.	Baseline and 12 weeks