Clinical Trial Summary
POPB is a consequence of the stretching of the nerve roots (C5, C6 + / C7, C8 or T1) of the
brachial plexus at birth. One third of patients will have sequelae. The most common is the
appearance of a deficit of passive and active mobilities in the movements in external
rotation of the shoulder especially in external rotation (RE) elbow to the body, despite
daily rehabilitation. At present, this stiffness is attributed to an imbalance between the
external rotator muscles (mainly infraspinatus) that would be atrophied and the internal
rotator muscles (subscapularis, pectoralis major, latissimus dorsi) that would be slightly
affected In case of no or negative RE from the age of 1 year, there is a surgical indication
to operate these children. At present, surgery to lift internal retractions is the only
therapy used, but despite this surgery and intensive rehabilitation, in some patients
mobility deficits re-occur in a few years. Thus, some teams systematically perform a muscle
transfer to strengthen the outer rotator muscles deficit during the initial operation. Other
teams (of which principal investigator is part) do this transfer only secondarily and in some
patients. Investigators lack objective and scientific criteria for the indication of this
second muscle transfer surgery and the etiology of retractions is not clearly defined.
In humans, subscapularis is innervated by the C5 and C6 roots, which are constantly affected
in POPB. It can be assumed that subscapularis may have an atrophy in POPB patients. To date,
no anatomopathological study has been performed on the internal / external rotator muscles of
patients with POPB that can give indications on recurrences.
Based on our clinical observations and literature data, the main hypothese is there is
amyotrophy of subscapularis and / or infraspinatus in POPB patients with shoulder stiffness.
