Bone Substitutes Clinical Trial
Official title:
Bioactive Glass Composite Implants in Cranial Bone Reconstruction
The purpose of this study is to study composites of bioactive glass and methylmetacrylate with glass fibre reinforcement in cranial bone defect reconstruction.
Traditional skull and facial bone reconstructions with hard tissues have a long history with
good clinical outcomes. However, they have certain disadvantages. The benefits of synthetic
materials are the avoidance of donor-site morbidity and scars, but also shorter
hospitalization time, lower expenses and known composition. Custom-made skull bone implant
can produced based on patients clinical need utilizing rapid prototyping technologies. This
will result in very high accuracy of the form of the skull defect.
Polymethylmetacrylate (PMMA) is one of the most widely used alloplastic material in surgery.
Bioactive glass S53P4 (BAG) particles have been used in various clinical indications. BAG
was added to composite implant of PMMA with glass fibre reinforcement to enhance bone
ingrowth to implant, and to utilize BAG`s antimicrobial effects. Ten patients cranial
defects are treated with composite implants.
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Observational Model: Case-Only, Time Perspective: Prospective
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